丹参酮ⅡA在心血管疾病中的研究进展  

Research progress of tanshinoneⅡA in cardiovascular diseases

作　　者：龙秀鹏 曾雨婷 陶顺 张哲 LONG Xiupeng;ZENG Yuting;TAO Shun;ZHANG Zhe(School of Medicine,Hunan University of Medicine,Huaihua,Hunan 418099,P.R.China;Department of Cardiology,Shenzhen People’s Hospital,Shenzhen,Guangdong 518020,P.R.China)

机构地区：[1]湖南医药学院医学院,湖南怀化418099 [2]深圳市人民医院心内科,广东深圳518020

出　　处：《华西医学》2024年第9期1487-1492,共6页West China Medical Journal

摘　　要：心血管疾病是全球发病率和死亡率最高的疾病之一。丹参酮ⅡA是丹参的主要活性成分之一,能够显著改善心功能。该文综述了丹参酮ⅡA保护心血管的机制,主要包括减少心肌细胞凋亡、抑制炎症反应、改善动脉粥样硬化、抑制心肌纤维化和抗氧化应激,并对丹参酮ⅡA的相关临床研究进行评估,以期为丹参酮ⅡA在心血管系统的后续研究与临床应用提供参考。Cardiovascular disease is one of the diseases with the highest morbidity and mortality in the world.TanshinoneⅡA is one of the main active components of Salvia miltiorrhiza,which can significantly improve heart function.In this paper,the mechanisms of cardiovascular protection by tanshinoneⅡA are reviewed,including reducing myocardial apoptosis,inhibiting inflammatory reaction,improving atherosclerosis,and inhibiting myocardial fibrosis and antioxidant stress,and the related clinical research of tanshinoneⅡA is evaluated,so as to provide reference for the following research and clinical application of tanshinoneⅡA in cardiovascular system.

关 键 词：丹参酮ⅡA 心血管疾病 临床试验 研究进展 

分 类 号：R259[医药卫生—中西医结合]