三七皂苷对人脐静脉内皮细胞增殖的影响  

Impact of Panax Notoginseng Saponins on Proliferation of Human Umbilical Vein Endothelial Cells

作　　者：俞方毅 宁波 叶劲超 梁一鸣 陈家祥 许智蕾 YU Fangyi;NING Bo;YE Jingchao;LIANG Yiming;CHEN Jiaxiang;XU Zhiei(Department of Neurosurgery,Guangzhou Red Cross Hospital,Guangzhou 510220,China)

机构地区：[1]广州市红十字会医院神经外科,广东广州510220

出　　处：《临床医学工程》2024年第9期1063-1064,共2页Clinical Medicine & Engineering

基　　金：广东省中医药科研项目面上项目(项目编号:20221305)。

摘　　要：目的探讨活血类中药成分三七总皂苷(PNS)对于人脐静脉内皮细胞(HUVECs)增殖的影响。方法体外培养HUVECs,分为空白对照组、PNS低浓度组(10 mg/L)、PNS高浓度组(50 mg/L),各组给予相应浓度药物干预,采用MTT法检测HUVECs增殖率。结果PNS低浓度组、PNS高浓度组的HUVECs增殖率均高于空白对照组(P<0.05)。结论PNS可促进HUVECs增殖,促进血管管腔的形成,对内皮细胞具有积极的影响,在维持血管健康和功能方面发挥着至关重要的作用。Objective To explore the impact of panax notoginseng saponins(PNS)on proliferation of human umbilical vein endothelial cells(HUVECs).Methods HUVECs were cultured in vitro and divided into blank control group,PNS low concentration group(10 mg/L)and PNS high concentration group(50 mg/L).Each group was given corresponding concentration of drug intervention,and the proliferation rate of HUVECs was detected by MTT assay.Results The proliferation rates of HUVECs in the PNS low concentration group and PNS high concentration group were higher than those of the blank control group(P<0.05).Conclusions PNS can promote the proliferation of HUVECs,and promote the formation of vascular lumen,which exerts positive effect on endothelial cells and plays a vital role in maintaining blood vessel health and function.

关 键 词：三七总皂苷 缺血性卒中 人脐静脉内皮细胞 增殖 

分 类 号：R285[医药卫生—中药学]