静脉血CD4检测在早期艾滋病患者筛查中的应用研究  

Application Study of Venous Blood CD4 Detection in the Early Screening of AIDS Patients

作　　者：季晓丽 卢莹莹 赵小瑞 JI Xiaoli;LU Yingying;ZHAO Xiaorui(Health Inspection and Testing Center,Disease Prevention and Control Center of wolong District,Nanyang 473000,China;Clinical Laboratory,Wolong District Maternal and Child Health Hospital,Nanyang 473000,china)

机构地区：[1]南阳市卧龙区疾病预防控制中心卫生检验检测中心,河南南阳473000 [2]南阳市卧龙区妇幼保健院检验科,河南南阳473000

出　　处：《临床医学工程》2024年第9期1101-1102,共2页Clinical Medicine & Engineering

摘　　要：目的探讨静脉血CD4^(+)检测在早期艾滋病患者筛查中的应用效果。方法选取2022年2月至2023年2月于我中心体检的200例艾滋病患者纳入观察组,另选择同期体检的200名健康人员纳入对照组。检测两组的CD4^(+)T淋巴细胞数与病毒载量(VL)水平,根据观察组CD4^(+)T淋巴细胞数检测结果进行分组。比较观察组与对照组CD4^(+)T淋巴细胞数;比较四个亚组VL水平,根据检测结果分析CD4^(+)T淋巴细胞数与VL的相关性。结果观察组CD4^(+)T淋巴细胞数少于对照组(P<0.05)。A组至D组艾滋病患者VL水平呈逐渐降低趋势(F=13.450,P<0.05)。Pearson相关性分析结果显示,CD4^(+)T淋巴细胞数与VL水平呈明显负相关(r=-0.604,P=0.007)。结论艾滋病患者患病期间,随着CD4^(+)T淋巴细胞数增加,VL水平逐渐降低;针对艾滋病患者进行CD4^(+)T淋巴细胞数与VL水平检测可明确艾滋病的发生,评估患者疾病严重程度。Objective To explore the application effect of venous blood CD4^(+)detection in the early screening of AIDS patients.Methods 200 AIDS patients with physical examination in our hospital from February 2022 to February 2023 were selected as observation group,and another 200 healthy people with physical examination during the same period were selected as control group.The CD4^(+)T lymphocyte count and viral load(VL)levels of two groups were detected,and the observation group were grouped according to the CD4^(+)T lymphocyte count test results.The CD4^(+)T lymphocyte count was compared between the observation group and the control group.The VL of the four subgroups were compared,and the correlation between the CD4^(+)T lymphocyte count and VL was analyzed based on the detection results.Results The number of CD4^(+)T lymphocytes in the observation group was lower than that in the control group(P<0.05).From group A to group D,the VL level of AIDS patients showed a gradually decreasing trend(F=13.450,P<0.05).Pearson correlation analysis showed that the CD4^(+)T lymphocyte count had significant negative correlation with VL level(r=-0.604,P=0.007).Conclusions During the AIDS,with the number of CD4^(+)T lymphocytes increases,the VL level gradually decreases.Detection of CD4^(+)T lymphocyte count and VL level in AIDS patients can clarify the occurrence of AIDS,and evaluate the disease severity.

关 键 词：CD4^(+)T淋巴细胞数 病毒载量 艾滋病 早期筛查 相关性 

分 类 号：R512.91[医药卫生—内科学]