血清胱抑素C和血清淀粉样蛋白A联合检测对早期糖尿病视网膜病变的诊断价值  

Diagnostic Value of Combined Detection of Serum Cystatin C and Serum Amyloid A for Early Diabetic Retinopathy

作　　者：马雯雯 潘美靖 邱壮忠 蔡洁娜 MA Wenwen;PAN Meijing;QIU Zhuangzhong;CAI Jiena(Clinical Laboratory,Puning People's Hospital,Puning 515300,China)

机构地区：[1]普宁市人民医院检验科,广东普宁515300

出　　处：《临床医学工程》2024年第9期1163-1164,共2页Clinical Medicine & Engineering

摘　　要：目的探讨血清胱抑素C(CysC)和血清淀粉样蛋白A(SAA)联合检测对早期糖尿病视网膜病变(DR)的诊断价值。方法选取2021年8月至2023年6月我院收治的120例2型糖尿病(T2DM)患者,按眼底病变程度不同分为NDR组(T2DM未伴DR,40例)、背景组(T2DM伴DR背景期,40例)和增殖组(T2DM伴DR增殖期,40例)。对比三组患者的血清CysC、SAA水平,分析血清CysC和SAA单独和联合检测对早期DR的诊断效能。结果三组患者血清CysC、SAA水平比较差异有统计学意义,其中增殖组>背景组>NDR组(P<0.05);绘制受试者工作特征(ROC)曲线结果显示,血清CysC和SAA联合检测诊断早期DR的曲线下面积(AUC)为0.713,高于各指标单独诊断(P<0.05)。结论血清CysC、SAA联合检测对早期DR的诊断价值较高,值得临床推广应用。Objective To explore the diagnostic value of combined detection of serum Cystatin C(CysC)and serum amyloid A(SAA)for early diabetic retinopathy(DR).Methods 120 patients with type 2 diabetes mellitus(T2DM)admitted to our hospital from August 2021 to June 2023 were selected and divided into NDR group(T2DM without DR,40 cases),background group(T2DM with DR background,40 cases)and proliferation group(T2DM with DR proliferation,40 cases)according to the degree of fundus lesions.The serum CysC and SAA levels among the three groups were compared,and the diagnostic efficacy of single and combined detection of serum CysC and SAA for early DR was analyzed.Results Statistical difference was found in the serum CysC and SAA levels among the three groups:the proliferation group>the background group>the NDR group(P<0.05).Receiver operating characteristic(ROC)curve results showed that the area under the curve(AUC)of combined detection of serum CysC and SAA in the diagnosis of early DR was 0.713,higher than the individual diagnosis of each indicator(P<0.05).Conclusions The combined detection of serum CysC and SAA has higher diagnostic value for early DR,which is worthy of clinical promotion and application.

关 键 词：血清胱抑素C 血清淀粉样蛋白A 2型糖尿病 早期糖尿病视网膜病变 诊断价值 

分 类 号：R587.2[医药卫生—内分泌]