艾滋病患者采用HAART辅助中药治疗的效果及对免疫功能重建的影响  

Effect of HAART as an adjunct to traditional Chinese medicine in the treatment of acquired immunodeficiency syndrome patients and its influence on immune function reconstruction

作　　者：朱思红 狄莎莎 徐艳松 ZHU Si-hong;DI Sha-sha;XU Yan-song(Zaozhuang Chest Hospital(Zaozhuang Cancer Hospital),Zaozhuang 277500,China)

机构地区：[1]枣庄市胸科医院(枣庄市肿瘤医院),277500

出　　处：《中国实用医药》2024年第18期39-42,共4页China Practical Medicine

摘　　要：目的分析艾滋病患者采用高效抗逆转录病毒治疗(HAART)辅助中药治疗的效果及对免疫功能重建的影响。方法选择采用HAART辅助中药治疗的艾滋病感染者30例。比较患者服用中药前、服用中药1个月、停用中药后的CD4+T淋巴细胞计数、血常规、肝功能、肾功能,治疗效果,不良反应发生情况。结果服用中药1个月和停用中药后患者的CD4+T淋巴细胞计数分别为(327.35±21.10)个/mm3、(329.10±21.18)个/mm3,明显高于服用中药前的(278.23±20.03)个/mm3,差异有统计学意义(P<0.05)。服用中药1个月及停用中药后患者的白细胞计数(6.10±1.56)×10^(9)/L、(6.07±1.50)×10^(9)/L,血小板计数(152.12±50.12)×10^(9)/L、(150.09±50.08)×10^(9)/L,血肌酐(511.32±86.79)、(511.30±86.73)μmol/L,血尿素氮(16.77±3.27)、(16.73±3.22)mmoL/L,血β2-微球蛋白(18.12±2.28)、(18.10±2.27)mg/L,明显低于服用中药前的(8.45±1.92)×10^(9)/L、(192.34±70.23)×10^(9)/L、(803.37±120.35)μmol/L、(27.38±5.42)mmol/L、(29.30±5.31)mg/L,淋巴细胞百分比(29.24±6.17)%、(29.27±6.19)%,明显高于服用中药前的(25.34±5.10)%,差异有统计学意义(P<0.05)。服用中药前、服用中药1个月、停用中药后的丙氨酸转氨酶、天冬氨酸转氨酶、直接胆红素水平无明显差异(P>0.05)。停用中药后,CD4+T淋巴细胞疗效:有效7例、稳定20例、无效3例。症状和体征疗效:有效18例、稳定7例、无效5例。治疗过程中未发现严重不良反应,对肝、肾无明显损害。结论HAART辅助中药治疗能够增强和稳定患者免疫功能,提高患者生存质量,部分患者恢复了劳动能力,主要实验室指标趋向良性改变,患者免疫功能(CD4+T淋巴细胞)阶段性上升、长期保持稳定或者延缓其下降速度。Objective To analyze the effect of highly active antiretroviral therapy(HAART)as an adjunct to traditional Chinese medicine in the treatment of acquired immunodeficiency syndrome patients and its influence on immune function reconstruction.Methods 30 cases of HIV-infected patients treated with HAART as an adjunct to traditional Chinese medicine were selected.Blood routine test,liver function,kidney function,CD4+cells and therapeutic effect were analyzed before,during and after taking the traditional Chinese medicine.The CD4+T lymphocyte count,blood routine,liver function,kidney function before taking the traditional Chinese medicine,after taking the traditional Chinese medicine for 1 month and after stopping the traditional Chinese medicine,therapeutic effect and adverse reaction were compared.Results The CD4+T-lymphocyte counts of the patients were(327.35±21.10)/mm3 and(329.10±21.18)/mm3 after taking the traditional Chinese medicine for 1 month and stopping the traditional Chinese medicine,which were significantly higher than(278.23±20.03)/mm3 before taking the traditional Chinese medicine,and the difference was statistically significant(P<0.05).After taking the traditional Chinese medicine for 1 month and stopping the traditional Chinese medicine,the white blood cell count were(6.10±1.56)×10^(9)/L and(6.07±1.50)×10^(9)/L,the platelet count were(152.12±50.12)×10^(9)/L and(150.09±50.08)×10^(9)/L,the serum creatinine were(511.32±86.79)and(511.30±86.73)μmol/L,the blood urea nitrogen were(16.77±3.27)and(16.73±3.22)mmol/L,and the bloodβ2-microglobulin were(18.12±2.28)and(18.10±2.27)mg/L,which were significantly lower than(8.45±1.92)×10^(9)/L,(192.34±70.23)×10^(9)/L,(803.37±120.35)μmol/L,(27.38±5.42)mmol/L,and(29.30±5.31)mg/L before taking the traditional Chinese medicine;the lymphocyte percentage were(29.24±6.17)%and(29.27±6.19)%,which was significantly higher than(25.34±5.10)%before taking the traditional Chinese medicine;the difference was statistically significant(P<0.05).There was no

关 键 词：艾滋病 高效抗逆转录病毒治疗 中药 免疫功能 CD4+T淋巴细胞 

分 类 号：R512.91[医药卫生—内科学]