化学发光免疫测定法对妊娠糖尿病伴乙肝患者的诊断价值分析  

Diagnostic value of chemiluminescent immunoassay in patients with gestational diabetes mellitus with hepatitis B

作　　者：齐向营 张立超 孙强[1] QI Xiang-ying;ZHANG Li-chao;SUN Qiang(Obstetrics Department,Zaozhuang Municipal Hospital,Zaozhuang 277100,China)

机构地区：[1]枣庄市立医院产科,277100

出　　处：《中国实用医药》2024年第18期85-87,共3页China Practical Medicine

摘　　要：目的探讨化学发光免疫测定法对妊娠糖尿病伴乙型病毒性肝炎(乙肝)患者的诊断价值。方法选取40例疑似妊娠糖尿病伴乙肝患者作为观察组,另以40例健康体检女性作为对照组。两组均实施化学发光免疫测定法检验。比较两组空腹胰岛素、空腹C肽水平及乙肝病毒标志物[乙肝表面抗原(HBsAg)、乙肝e抗原(HBeAg)、乙肝e抗体(HBeAb)、乙肝核心抗体(HBcAb)、乙肝表面抗体(HBsAb)]阳性检出情况;分析化学发光免疫测定法对妊娠糖尿病伴乙肝患者的诊断效能。结果观察组患者的空腹胰岛素水平(5.14±2.33)μIU/L和空腹C肽水平(1.15±0.32)ng/ml均低于对照组的(7.62±2.25)μIU/L、(1.68±0.27)ng/ml,差异具有统计学意义(P<0.05)。观察组患者HBsAg、HBsAb、HBeAg、HBeAb、HBcAb阳性检出率分别为60.00%、62.50%、75.00%、50.00%、65.00%,均高于对照组的25.00%、22.50%、10.00%、12.50%、20.00%,差异具有统计学意义(P<0.05)。40例疑似妊娠糖尿病伴乙肝患者,经化学发光免疫测定法检出妊娠糖尿病伴乙肝患者共31例,即阳性31例,阴性9例;化学发光免疫测定法对妊娠糖尿病伴乙肝的诊断灵敏度为87.88%(29/33),特异度为71.43%(5/7),准确度为85.00%(34/40)。结论对妊娠糖尿病伴乙肝患者实施化学发光免疫测定法检验的诊断价值显著,其诊断准确度和灵敏度较高。Objective To explore the diagnostic value of chemiluminescent immunoassay in patients with gestational diabetes mellitus with hepatitis B.Methods 40 patients of suspected gestational diabetes with hepatitis B were taken as the observation group,and 40 healthy famale subjects during the same period were taken as the control group.Chemiluminescent immunoassay was performed in both groups to compare the fasting insulin,fasting C-peptide levels and the detection of hepatitis B virus markers[hepatitis B surface antigen(HBsAg),hepatitis B e antigen(HBeAg),hepatitis B e antibody(HBeAb),hepatitis B core antibody(HBcAb),hepatitis B surface antibody(HBsAb)]positivity between the two groups.The efficacy of chemiluminescence immunoassay in the diagnosis of gestational diabetes mellitus with hepatitis B was analyzed.Results The observation group had fasting insulin level of(5.14±2.33)μIU/L and fasting C-peptide level of(1.15±0.32)ng/ml,which were lower than(7.62±2.25)μIU/L and(1.68±0.27)ng/ml in the control group,and the differences were statistically significant(P<0.05).The detection rates of HBsAg,HBsAb,HBeAg,HBeAb and HBcAb positivity in the observation group were 60.00%,62.50%,75.00%,50.00%and 65.00%,which were higher than 25.00%,22.50%,10.00%,12.50%and 20.00%in the control group,and the difference was statistically significant(P<0.05).Among the 40 patients with suspected gestational diabetes mellitus with hepatitis B,a total of 31 cases were detected by chemiluminescence immunoassay,i.e.,31 cases were positive and 9 cases were negative;the diagnostic sensitivity of chemiluminescence immunoassay for gestational diabetes mellitus with hepatitis B was 87.88%(29/33),the specificity was 71.43%(5/7)and the accuracy was 85.00%(34/40).Conclusion Chemiluminescent immunoassay has significant value for the diagnosis of gestational diabetes with hepatitis B,and its diagnostic accuracy and sensitivity are high.

关 键 词：妊娠糖尿病 乙型病毒性肝炎 化学发光免疫测定法 诊断价值 

分 类 号：R714.256[医药卫生—妇产科学] R512.62[医药卫生—临床医学]