内托生肌法治疗肉芽肿性乳腺炎溃后期的临床疗效  

Clinical efficacy of endotropic muscle-generating therapy in treating late-stage ulcerative granulomatous mastitis

作　　者：朱彩霞[1] 邹素文 区俏彦 刘丹曼 陈蒋玲 谢四梅[1] 张安秦[1] ZHU Caixia;ZOU Suwen;OU Qiaoyan;LIU Danman;CHEN Jiangling;XIE Simei;ZHANG Anqin(Department of Breast Center,Guangdong Women and Children’s Hospital,Guangzhou 511400,China)

机构地区：[1]广东省妇幼保健院乳腺疾病防治中心,广东广州511400

出　　处：《广州医药》2024年第8期888-894,902,共8页Guangzhou Medical Journal

基　　金：广东省中医药局科研项目(20222018)。

摘　　要：目的研究内托生肌法治疗肉芽肿性乳腺炎溃后期的临床疗效。方法63例符合肉芽肿性乳腺炎溃后期的患者,分为西药组31例和中药组32例。西医药组予常规激素、抗生素等治疗,中药组予内托生肌法,加减组方,两组治疗时间为6个月。比较两组患者的疾病转归、乳房外形评价、临床症状观察评分等指标。结果中药组6个月治愈率高于西药组,中药组临床治愈18例(56.2%)、痊愈11例(34.4%),相较于西药组临床治愈11例(35.5%)和痊愈9例(29%);治疗后中药组乳房外形评价优于西药组,中药组临床症状评分较低,组间比较差异具有统计学意义。两组患者治疗前后免疫球蛋白IgA、IgG、IgM水平比较差异均未见统计学意义。中药组相较于西药组不良反应更少,患者依从性更高。结论内托生肌法治疗肉芽肿性乳腺炎溃后期能促进肉芽肿创面愈合,加快肉芽组织新生,改善破溃流脓症状以及在恢复乳房外观方面具有明显的优势。Objective To study the clinical efficacy of endotropic muscle-generating therapy in treating late-stage ulcerative granulomatous mastitis.Methods Sixty-three eligible patients were included in the western medicine group(31 cases)and the traditional Chinese medicine group(32 cases).The western medicine group received conventional hormones and antibiotics,while the traditional Chinese medicine group received the endotropic muscle-generating method with adjustments.The treatment duration for both groups was six months.Disease regression,breast shape evaluation,clinical symptom observation scores,and other relevant indices of both groups were compared.Results The study found that the six-month cure rate in the traditional Chinese medicine group(56.2%clinically cured,34.4%cured)exceeded that of the western medicine group(35.5%clinically cured,29%cured).Breast appearance evaluation in the traditional Chinese medicine group significantly better that of the western medicine group post-treatment,and clinical symptom scores were lower,demonstrating a statistically significant difference.Before and after treatment,there was no significant difference in the levels of immunoglobulins A,G,and M observed between the two groups.The traditional Chinese medicine group exhibited fewer side effects and higher patient compliance compared to the western medicine group.Conclusions The endotropic muscle-generating method,when employed to treat granulomatous mastitis in the late ulcerative stage,proves effective in promoting granulomatous wound healing,accelerating the generation of new granulation tissue,and improving ulceration and pus flow symptoms.Additionally,it contributes to the restoration of breast appearance.

关 键 词：肉芽肿性乳腺炎 溃后期 内托生肌法 

分 类 号：R655.8[医药卫生—外科学]