电子加速器光中子源生产医用同位素的模拟研究  

Simulation study of medical isotope production using electron accelerator-driven photoneutron source

作　　者：张子雄 李凯旋 魏强林[1,2] 刘义保 张勤拓[1,2] ZHANG Zixiong;LI Kaixuan;WEI Qianglin;LIU Yibao;ZHANG Qintuo(Engineering Research Center of Nuclear Technology Application,Ministry of Education(East China University of Technology),Nanchang 330013,China;School of Nuclear Science and Engineering,East China University of Technology,Nanchang 330013,China;Engineering Technology Research Center of Nuclear Radiation Detection and Application,Nanchang 330013,China)

机构地区：[1]东华理工大学核技术应用教育部工程研究中心,南昌330013 [2]东华理工大学核科学与工程学院,南昌330013 [3]江西省核辐射探测及应用工程技术研究中心,南昌330013

出　　处：《核技术》2024年第9期35-42,共8页Nuclear Techniques

基　　金：教育部核技术应用教育部工程研究中心开放基金项目(No.HJSJYB2021-9);东华理工大学博士启动基金项目(No.DHBK2021005);江西省质谱科学与仪器重点实验室开放基金项目(No.JXMS202111)资助。

摘　　要：光核反应和紧凑型中子源是生产医用同位素的新兴工具,东华理工大学正在建设一种电子加速器驱动的光中子源(East China Accelerator&Neutron Source,ECANS),用于医用同位素生产研究。在分析W-^(100)Mo光中子源的中子产额及^(99)Mo产量的基础上,建立了中子能量调节层和中子反射层组成的放射性同位素产生模型,对不同天然氧化物材料(MoO_(3)、Lu_(2)O_(3)、Y_(2)O_(3))进行了放射性同位素的产生模拟及伴生产物分析,探讨了光核反应中子源生产医用同位素的可行性。研究结果显示:在高富集^(100)Mo靶材中^(99)Mo同位素的产量为2.00 TBq·d^(-1),在氧化物靶材中^(99)Mo的产量为0.64 TBq·d^(-1)、^(177)Lu的产量为0.67 TBq·d^(-1)以及90Y的产量为2.11 TBq·d^(-1)。此外,分析了天然氧化物在辐照条件下放射性杂质的含量,为后续分离纯化提供数据参考。[Background]Photonuclear reactions and compact neutron sources have emerged as promising tools for the production of medical isotopes,providing alternatives to conventional reactor-based high-enriched uranium methods.East China University of Technology(ECUT)is currently constructing an electron accelerator-driven photoneutron source(ECANS)for medical isotope production research.[Purpose]This study aims to investigate the photonuclear reaction with ^(100)Mo isotope and utilize the generated neutrons for isotopic production.[Methods]Firstly,the photonuclear reactions of ^(100)Mo was analyzed in details.The neutron spectrum and activation yield of ^(99)Mo within a high purity ^(100)Mo target were investigated.Then,a new model to produce medical isotopes was established on the basis of the ECANS photonuclear source,comprising neutron energy modulation layer and neutron reflection layer.Finally,the production yields of ^(99)Mo,177Lu,and ^(90)Y in various natural oxides were calculated and the feasibility of using photonuclear sources for medical isotope production was assessed.The content of radioactive impurities in natural oxides under irradiation conditions was also analyzed.[Results]Simulation results demonstrate that photo-nuclear reactions can effectively produce medical isotopes such as ^(99)Mo,^(177)Lu,and ^(90)Y,with respective activities of 0.64 TBq·d^(-1),0.67 TBq·d^(-1),and 2.11 TBq·d^(-1).And in the high purity ^(100)Mo target,the daily output of ^(99)Mo reaches 2.00 TBq·d^(-1).[Conclusions]This study demonstrates the feasibility of using the photodisintegration reaction of ^(100)Mo as a neutron source for secondary production of medical isotopes,offering the potential to enhance the economic viability of isotope production.The approach of this study provides preliminary insights for subsequent separation and purification processes,hence has certain reference value for the development of tools for radioactive isotope production.

关 键 词：光核反应 中子源 电子直线加速器 医用同位素 

分 类 号：TL92[核科学技术—核燃料循环与材料]