臀肌腱炎、原发性髋关节病可能导致髂胫束综合征—一项孟德尔随机化研究  

Gluteal tendinitis and primary coxarthrosis may lead to iliotibial band syndrome:a Mendelian randomization study

作　　者：姚辰 李文佳 庞瑞明 周继红 YAO Chen;LI Wenjia;PANG Ruiming;ZHOU Jihong(Department of Orthopedics and Traumatology,Guangzhou University of Chinese Medicine,Shenzhen 518000,China;Department of Pulmonary and Critical Care Medicine,Shenzhen Bao'an Traditional Chinese Medicine Hospital,Guangzhou University of Chinese Medicine,Shenzhen 518000,China)

机构地区：[1]广州中医药大学附属宝安中医院骨伤科一区,广东深圳518000 [2]广州中医药大学附属宝安中医院呼吸与危重症学科,广东深圳518000

出　　处：《南方医科大学学报》2024年第9期1821-1830,共10页Journal of Southern Medical University

摘　　要：目的利用孟德尔随机化方法,分析臀肌腱炎、原发性髋关节病与髂胫束综合征发生的潜在因果关系。方法利用已知臀肌腱炎、原发性髋关节病及髂胫束综合征的GWAS数据,筛选出高相关性单核苷酸多态性(SNPs),采用随机效应逆方差加权法(IVW)、MR-Egger回归和加权中位数法进行MR分析,判断臀肌腱炎及原发性髋关节病和髂胫束综合征是否存在因果关系,并通过异质性检验、多效性检验及敏感性分析、临床数据验证分析结果的可靠性。结果臀肌腱炎与髂胫束综合征呈显著正相关[IVW:OR(95%CI)=1.32(1.03~1.68),P=0.026]。原发性髋关节病与髂胫束综合征呈显著正相关[IVW:OR(95%CI)=1.40(1.06~1.84),P=0.017]。结论臀肌腱炎及原发性髋关节病可能增加髂胫束综合征的发病风险。Objective To analyze the causal relationship of gluteal tendinitis and primary coxarthrosis with the occurrence of iliotibial band syndrome using Mendelian randomization.Methods The GWAS data of gluteal tendinitis,primary coxarthrosis and iliotibial band syndrome were screened for high correlation single-nucleotide polymorphisms(SNPs).Mendelian randomization analysis was performed using random-effects inverse variance weighting(IVW),MR-Egger regression,and weighted median method to determine whether gluteal tendinitis and primary coxarthrosis were causally related with iliotibial band syndrome.Heterogeneity test,multiple validity test and sensitivity analysis,and clinical data analysis were used to verify the reliability of the results.Results Both gluteal tendinitis[IVW:OR(95%CI)=1.32(1.03-1.68),P=0.026]and primary coxarthrosis[IVW:OR(95%CI)=1.40(1.06-1.84),P=0.017]was positively correlated with iliotibial band syndrome.Conclusion Gluteal tendinitis and primary coxarthrosis may increase the risk of iliotibial band syndrome.

关 键 词：臀肌腱炎 原发性髋关节病 髂胫束综合征 孟德尔随机化 

分 类 号：R686.1[医药卫生—骨科学] R684[医药卫生—外科学]