humanin在代谢性疾病作用中的研究进展  

Progress in role of humanin in metabolic diseases

作　　者：姜枫 姚婷婷[1] 衣雪洁[1] 高海宁[1] JIANG Feng;YAO Tingting;YI Xuejie;GAO Haining(Shenyang Sport University,Shenyang 110002,China)

机构地区：[1]沈阳体育学院,辽宁沈阳110002

出　　处：《中国病理生理杂志》2024年第9期1736-1743,共8页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.12072202);辽宁省高等学校基本科研项目(No.JYTMS20231332)。

摘　　要：发病率逐年增高的代谢性疾病对人们的生命安全造成极大威胁,寻找治疗代谢性疾病的有效靶点成为了亟待解决的问题。humanin(HN)是一种由线粒体DNA转录翻译的具有24个氨基酸的线性多肽,过去的研究表明它具有神经细胞保护作用。近年来的研究发现HN与机体的糖脂代谢调节密切相关,并且在动物实验中使用HN或HN类似物可以有效治疗多种代谢性疾病。因此,本文回顾了HN的基础生物学功能与信号传导机制,并系统全面地总结了HN在2型糖尿病、非酒精性脂肪性肝病、动脉粥样硬化和多囊卵巢综合征中的作用机制与治疗效果,旨在探讨HN作为代谢性疾病防治靶点的潜力。The increasing prevalence of metabolic diseases poses a significant threat to public health,highlighting the urgent need to identify effective therapeutic targets.Humanin(HN),a 24-amino acid linear peptide synthesized from mitochondrial DNA,has been previously acknowledged for its neuroprotective properties.Recent research indicates that HN can regulate glucose and lipid metabolism and has shown promise in treating metabolic disorders in animal models using either HN or its analogs.This review outlines the fundamental biological functions and signal transduction mechanisms of HN,and comprehensively evaluates its role and therapeutic potential in type 2 diabetes mellitus,nonalcoholic fatty liver disease,atherosclerosis and polycystic ovary syndrome,aiming to examine the potential of HN as a target for the prevention and treatment of metabolic diseases.

关 键 词：HUMANIN 代谢性疾病 2型糖尿病 非酒精性脂肪性肝病 动脉粥样硬化 多囊卵巢综合征 

分 类 号：R589[医药卫生—内分泌] R363[医药卫生—内科学] R711.75[医药卫生—临床医学]