Dermal thickness,rather than drug concentration and injection speed,influences the effective area of botulinum toxin type A in the dermis  

作　　者：Yixin Sun Wangfei Mo Yunzhu Li Ruijia Dong Cheng Chen Jing Gao Nanze Yu Xiao Long 

机构地区：[1]Department of Plastic Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100730,China [2]Department of Plastic and Burns Surgery,West China Hospital,Sichuan University,Chengdu,610041,China [3]Department of Plastic and Reconstructive Surgery,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing,102218,China [4]Department of Ultrasound,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100730,China

出　　处：《Chinese Journal of Plastic and Reconstructive Surgery》2024年第3期130-134,共5页中国整形与重建外科（英文）

基　　金：supported by the National High Level Hospital Clinical Research Funding(grant nos.2022-PUMCH-B-041,2022-PUMCH-A-210,and 2022-PUMCH-C-025).

摘　　要：Background:Recently,microbotulinum,a new technique that involves injecting botulinum toxin type A(BoNTA)microdroplets into superficial cutaneous tissue,has gained popularity.The precise distribution of BoNTA in the targeted area profoundly affects outcomes.Many factors may influence the effective area of BoNTA in the dermis.This study aimed to determine the dermal distribution properties of BoNTA to guide microbotulinum injection.Methods:Ten healthy males aged 18–65 years without BoNTA treatment in the previous year were recruited to receive intradermal injections in the chest and back.Ultrasound was used to ensure the intradermal delivery of injections and measure the dermal thickness.The minor iodine starch test was performed at baseline and 3 days,7 days,21 days,1 month,and 2 months after treatment.Results:All participants received intradermal injections.The dermis was thinner on the chest(thickness,0.20±0.03 cm)than on the back(thickness,0.39±0.07 cm)(P<0.05).An injection in the thicker dermis had a significantly smaller effective area at every follow-up visit.The drug concentration did not affect the effective area except at 3 days after treatment.Injection speed did not influence the effective area at any follow-up visits.Conclusion:An injection in a thicker dermis leads to a smaller effective area for intradermal injections.When the BoNTA dose is the same,the drug concentration and injection speed do not matter.

关 键 词：Botulinum toxin type A Effective area Microbotulinum 

分 类 号：R62[医药卫生—整形外科]