Dual innervation method to preserve erectile function following prostatectomy  

作　　者：Nadia Hui Shan Sim Allen Sim Dayna Sim Bien-Keem Tan Allen Wei-Jiat Wong 

机构地区：[1]Plastic,Reconstructive and Aesthetic Surgery Service,Sengkang General Hospital,544886,Singapore [2]Department of Urology,Mount Alvernia Hospital Singapore,574623,Singapore [3]Department of General Surgery,Sengkang General Hospital,544886,Singapore [4]Department of Plastic,Reconstructive and Aesthetic Surgery,Singapore General Hospital,169608,Singapore

出　　处：《Chinese Journal of Plastic and Reconstructive Surgery》2024年第3期159-160,共2页中国整形与重建外科（英文）

基　　金：The funding for this project was provided by SingHealth Duke-NUS Musculoskeletal Sciences Academic Clinical Program Pitch for Fund Research Support Grant 2019.

摘　　要：Prostate cancer is the second most prevalent cancer in men.Robot-assisted radical prostatectomy(RARP)has altered the landscape of prostate cancer treatment.Despite the excellent oncological outcomes associated with RARP,the rate of erectile dysfunction(ED)remains high.Primary repair of disrupted cavernous nerves with interpositional nerve grafts has been described;however,the outcomes have been inconsistent.We hypothesize that this is attributed to Schwann cell atrophy and axonal regeneration limitations caused by long nerve grafts.We proposed the use of nerve transfer to support axonal regrowth via an inter-positional graft with additional donor axons.A cadaveric study was performed to evaluate the anatomical feasibility of a vastus lateralis nerve(VLN)transfer to the distal recipient cavernous nerve stump.The VLN is long with multiple branching patterns that allow tension-free coaptation of the cavernous nerve.We postulate that a dual innervation method using VLN nerve transfer together with interpositional nerve graft repair of the transacted cavernous nerves may improve the outcomes of ED post-RARP.

关 键 词：Erectile dysfunction Prostatectomy Interposition nerve graft Nerve transfer Vastus lateralis nerve 

分 类 号：R699[医药卫生—泌尿科学]