2型糖尿病患者24 h尿钠排泄及IL-18水平与尿白蛋白的相关性研究  

Correlation between 24-hour Urinary Sodium Excretion,IL-18 Level and Urinary Albumin in Patients with Type 2 Diabetes Mellitus

作　　者：谭龙巧 史丽 刘建芳 夏雪梅 朱丽 徐玉善[1] TAN Longqiao;SHI Li;LIU Jianfang;XIA Xuemei;ZHU Li;XU Yushan(Dept.of Endocrinology,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032;Dept.of Endocrinology,Kunming Second People’s Hospital,Kunming Yunnan 650201,China)

机构地区：[1]昆明医科大学第一附属医院内分泌一科,云南昆明650032 [2]昆明市第二人民医院内分泌科,云南昆明650201

出　　处：《昆明医科大学学报》2024年第9期49-55,共7页Journal of Kunming Medical University

基　　金：云南省科技厅科技计划项目(202301AY070001-290、202301AU070176);云南省“兴滇英才支持计划”青年人才专项基金(RLQ820220008);云南省“兴滇英才支持计划”名医专项基金(RLMY20220001);云南省代谢性疾病临床医学研究中心项目(202102AA100056);云南省内分泌代谢疾病临床医学中心项目(YWLCYXZXXYS20221005)。

摘　　要：目的以24 h尿钠排泄水平(24 h UNa)作为钠摄入量评估指标,评估不同钠盐的摄入水平与血清炎症因子对2型糖尿病(T2DM)患者尿白蛋白(UA)发生风险的影响。方法纳入T2DM患者130例,依据尿白蛋白/肌酐比值(UACR)水平分为UA阳性组60例和UA阴性组70例。收集患者的临床资料,检测炎性因子及24 h尿液相关指标。采用Spearman相关分析T2DM患者临床指标与UACR的相关性;二元Logistic回归分析T2DM患者临床指标对UA的影响;二分类回归法分析24 h UNa和IL-18关联对UA的影响。结果24 h UNa水平(OR=1.019,95%CI 1.003~1.035,P=0.017)与IL-18(OR=1.204,95%CI 1.060~1.368,P=0.004)是T2DM患者UA阳性的独立危险因素。联合分析提示,与低钠低IL-18组比较,高钠高IL-18组UA阳性风险显著增加(OR=10.774,95%CI 2.105~55.155,P=0.004)。结论24 h UNa、IL-18水平升高是T2DM患者UA发生的危险因素。Objective To evaluate the effects of different sodium intake levels and serum inflammatory factors on the risk of urinary albumin(UA)in patients with type 2 diabetes mellitus(T2DM)by using 24 h UNa as an indicator of sodium intake.Methods 130 T2DM patients were included and divided into a UA-positive group(60 cases)and a UA-negative group(70 cases)according to urinary albumin/creatinine ratio(UACR).Clinical data of patients were collected and inflammatory factors and 24-hour urine-related indexes were detected.spearman correlation analysis was used to analyze the correlation between clinical indicators and UACR in T2DM patients.The effect of clinical indicators on UA in T2DM patients was analyzed by binary Logistic regression.The effect of 24 h UNa and IL-18 correlation on UA was analyzed by binary regression method.Results 24 h UNa level(OR=1.019,95%CI 1.003~1.035,P=0.017)and IL-18(OR=1.204,95%CI1.060~1.368,P=0.004)were independent risk factors for positive UA in T2DM patients.Conjoint analysis suggested a significantly increased risk of UA positive in the high-sodium and high-IL-18 groups(OR=10.774,95%CI 2.105~55.155,P=0.004)compared with the low-sodium and low-IL-18 groups.Conclusion Increased levels of 24 h UNa and IL-18 are risk factors for UA in T2DM patients.

关 键 词：2型糖尿病 尿白蛋白 24 h尿钠排泄 IL-18 

分 类 号：R587.2[医药卫生—内分泌]