急性创伤性颅脑损伤入院即刻检验相关指标分析  

Analysis of Relevant Indicators for Acute Traumatic Head Injury Upon Immediate Admission

作　　者：聂晓改 张云芳 庄杉杉 涂坤 王娇 NIE Xiaogai;ZHANG Yunfang;ZHUANG Shanshan;TU Kun;WANG Jiao(Dept.of Medical Laboratory,Yan’an Hospital of Kunming,Kunming Yunnan 650051,China;Dept.of Neurology,Yan’an Hospital of Kunming,Kunming Yunnan 650051,China)

机构地区：[1]昆明市延安医院医学检验科,云南昆明650051 [2]昆明市延安医院神经内科,云南昆明650051

出　　处：《昆明医科大学学报》2024年第9期122-128,共7页Journal of Kunming Medical University

基　　金：昆明市卫生健康委员会卫生科研基金资助项目(2022-11-01-013)。

摘　　要：目的探索与急性创伤性颅脑损伤发病及预后紧密联系的检验指标。方法通过收集昆明市延安医院创伤中心成立后2022年10月至2023年6月经由急诊科收治的156例颅脑损伤患者资料,对患者的性别、年龄、预后、入院即刻实验室检查等结果进行统计分析。结果急性TBI患者男性发病率明显高于女性,2.62∶1,且中重度及预后不良患者男性均明显高于女性,差异有统计学意义(P<0.05)。主要发病年龄在39~72岁,预后不良患者年龄明显高于预后良好患者,差异有统计学意义(P<0.05)。颅脑损伤患者入院即刻WBC、CRPH、AST、GLU、D-Dimer、S100β、IL-6较正常对照组明显升高,中重组WBC、CRPH、AST高于轻型组(P<0.05);预后不良组CRPH、AST、GLU水平高于预后良好组,差异有统计学意义(P<0.05)。结论入院即刻检验指标如WBC、CRPH、AST、GLU等可能与急性创伤性颅脑损伤严重程度或不良预后相关,临床医生应重点关注并及时针对性干预治疗,可改善不良结局。Objective To explore the test indicators closely related to the incidence and prognosis of acute traumatic head injury.Methods The data of 156 patients with head injuries admitted to the emergency department from October 2022 to June 2023 after the establishment of the trauma center of Yan'an Hospital of Kunming were collected.The gender,age,prognosis,and laboratory tests immediately after admission were statistically analyzed.Results The incidence rate of acute TBI patients was significantly higher in males than in females,with a ratio of 2.62∶1,and the incidence of moderate to severe and poor prognosis was significantly higher in males than females,and the difference was statistically significant P<0.05.The main age of onset was 39~72 years old,and the age of patients with poor prognosis was significantly higher than that of patients with good prognosis,and the difference was statistically significant,P<0.05.The tests immediately upon admission WBC,CRPH,AST,GLU,D-Dimers,S100βand IL-6 in the patients with craniocerebral injury were significantly higher than those in the normal control group,and the recombinant WBC,CRPH and AST were higher than those in the mild group.The levels of CRPH,AST and GLU in the poor prognosis group were higher than those in the good prognosis group,and the difference was statistically significant P<0.05.Conclusion Immediate test markers,such as WBC,CRPH,AST,GU,etc.,may be related to the severity or poor prognosis of acute traumatic head injury,and clinicians should pay attention to and timely targeted intervention and treatment to improve adverse outcomes.

关 键 词：创伤性颅脑损伤 创伤诊治中心 预后 

分 类 号：R641[医药卫生—外科学]