重庆地区敏感性皮肤人群皮肤特点和斑贴试验研究  

Study on skin characteristics and patch test of sensitive skin population in Chongqing

作　　者：吕静[1] 江阳[1] 王祖红[1] 王莎 李佳佳 李玲 LYU Jing;JIANG Yang;WANG Zuhong;WANG Sha;LI Jiajia;LI Ling(Department of Dermatology,Chongqing Hospital of Traditional Chinese Medicine,Chongqing City,400011,China)

机构地区：[1]重庆市中医院皮肤科,重庆400011

出　　处：《中国医疗美容》2024年第8期18-23,共6页China Medical Cosmetology

基　　金：重庆市药品不良反应监测中心项目(H0120230001)。

摘　　要：目的 分析重庆地区敏感性皮肤(sensitive skin,SS)人群的皮肤特点及化妆品相关过敏因素,评估SS人群和正常人群的斑贴试验结果是否存在差异,为化妆品不良反应起到预警作用并提供客观的风险评估依据。方法 收集重庆市中医院皮肤科69例乳酸刺痛试验(lactate stimulation tes,LAST)阳性及临床评估为SS的志愿者作为试验组,70例LAST阴性的正常人群为对照组,分别完善受试者自评、医师临床评估、无创皮肤生理指数测定(包括皮肤水分含量、经皮水分丢失、皮肤红斑指数、油脂含量、pH值5项指标)及人体皮肤封闭型斑贴试验4项测试,对上述结果综合判定并汇总分析。结果 试验组乳酸刺痛评分和总感觉评分均大于对照组,差异有统计学意义(P<0.001),试验组和对照组乳酸刺痛评分分别为(3.54±0.65)分、(2.71±0.87)分,差异有统计学意义(P<0.05)。试验组人体封闭型斑贴试验显示,57例(82.61%)出现≥1种成分阳性反应,44例(63.77%)出现≥3种成分阳性反应;对照组41例(58.57%)出现≥1种成分阳性反应,16例(22.86%)出现≥3种成分阳性反应。最易引起SS人群化妆品不良反应的变应原分别为月桂基葡糖苷、没食子酸月桂酯、没食子酸辛酯、硫酸镍、葵基葡糖苷、山梨坦油酸酯、甲基二溴戊二腈;正常人群中常见变应原分别为没食子酸月桂酯、没食子酸辛酯、月桂基葡糖苷、山梨醇倍半油酸酯、山梨坦油酸酯、硫柳汞、硫酸镍。试验组面部瘙痒、刺痛、灼热、红斑、脱屑评分均高于对照组,差异有统计学意义(P<0.05);试验组和对照组面部皮肤油脂、水分含量、经皮水分丢失、红斑指数、p H值均有显著性差异(P<0.05),试验组皮肤屏障功能受损。结论 重庆地区敏感性皮肤人群皮肤屏障有不同程度受损,伴自觉症状及客观体征,乳酸刺痛评分明显升高,对多种化妆品成分过敏,最常见的是月桂基葡糖苷、没食Objective To analysis the skin characteristics and cosmetics related allergic factors of sensitive skin populations in Chongqing area and evaluate the differences in patch test results between the SS population and the normal population,in order to provide guidance for local cosmetic adverse reaction monitoring and risk assessment.Methods Seventy-one volunteers who are positive for lactate stimulation test(LAST)and clinically evaluated as SS as the test group,70 normal individuals with LAST negative as the control group,improveing subject self-evaluation,physician clinical evaluation,non-invasive skin physiological index measurement(including skin moisture content,trans epidermal water loss,skin hemoglobin content,skin oil contentand and skin pH),and human skin closed patch test respectively,results were conducted and analyzed after the experiment.Results The lactate stinging score and overall feeling rating in the test group were higher than those in the control group,and the differences are statistically significant,the scores of the two groups were(3.54±0.65)and(2.71±0.87)respectively(P<0.05).The cosmetic ingredient patch test in the test group showed that 57 cases(82.61%)were positive reactions for≥1 component,while 44 cases(63.77%)positive reactions for≥3 components,the allergens include lauryl glucoside(36.23%),lauryl gallate(36.23%),octyl gallate(26.09%),nickel sulfate(23.19%),sunyl glucoside(21.74%),orbitan oleate(20.29%)and methyl dibromoglutaryl cyanide(20.29%).The cosmetic ingredient patch test in the control group showed that 41cases(58.75%)were positive reactions for≥1 component,while 16 cases(22.86%)positive reactions for≥3 components,the allergens include lauryl gallate(20.29%),octyl gallate(18.57%),laurylglucoside(18.57%),sorbitol sesquioleate(15.71%),sorbitan oleate(11.43%),thiomersal(8.57%)and nickel sulfate(8.57).The scores of itching,stinging,burning,erythema and scaling in the control group were significantly lower than those in the experimental group(P<0.005);there were significant

关 键 词：敏感性皮肤 皮肤特点 皮肤屏障 斑贴试验 

分 类 号：R62[医药卫生—整形外科]