精准光联合异维A酸治疗酒糟鼻的临床疗效及对皮损积分及不良反应的影响  

Clinical efficacy of precision light combined with isotretinoin in the treatment of rosacea and its influence on skin lesion score and adverse reactions

作　　者：王文娟 杨淑华 齐晨晨 WANG Wenjuan;YANG Shuhua;QI Chenchen(Department of Laser Cosmetology,Henan Jingcheng skin traditional Chinese medicine hospital,Henan Province,450000,China)

机构地区：[1]河南京城皮肤中医院激光美容科,河南郑州450000

出　　处：《中国医疗美容》2024年第8期23-27,共5页China Medical Cosmetology

摘　　要：目的 探究精准光联合异维A酸在酒糟鼻中的应用效果,分析其对患者皮损积分及不良反应的影响。方法 选取2020年5月至2021年5月河南京城皮肤中医院激光美容科收治的60例中重度玫瑰痤疮患者,将其分为A组、B组、C组,每组20例。A组患者口服异维A酸治疗,B组患者应用精准光治疗,C组患者应用异维A酸联合精准光治疗。三组均治疗12周,观察临床疗效以及皮损积分,比较3组患者治疗前后皮肤病生活质量指数,统计不良反应(红斑加重、色素沉着、丘疹增多/面积增大、其他胃肠道反应)发生情况。结果 A组治疗总有效率65.00%(13/20),B组75.00%(15/20),C组95.00%(19/20),组间差异有统计学意义(P<0.05);C组患者治疗后皮损积分随疗程逐渐下降,且均低于同期A、B组(P<0.05);3组治疗后各项皮损积分较治疗前均下降,且C组优于A组、B组(P<0.05);C组不良反应发生率低于A组、B组(P<0.05)。结论 精准光及异维A酸在治疗酒糟鼻中均表现出良好效果,两者联合应用的情况下疗效更好且治疗安全性高,对提高酒糟鼻患者生活质量,改善皮损症状有积极效果,值得临床推广应用。Objective To explore the application effect of precision light combined with isotretinoin in rosacea,and analyze its impact on the patient's skin lesion score and adverse reactions.Methods A total of 60 patients with moderate to severe rosacea admitted to the Department of laser cosmetology of Henan Jingcheng skin traditional Chinese medicine hospital from May 2020 to may 2021 were selected and divided into three groups,A,B and C,with 20 cases in each group.Patients in group A were treated with oral isotretinoin,patients in group B were treated with precision light therapy(DPL),and patients in group C were treated with isotretinoin combined with DPL.All the three groups were treated for 12 weeks,and the clinical efficacy and skin lesion scores were observed.The dermatological quality of life index(DLQI)of the three groups before and after treatment was compared,and the occurrence of adverse reactions(erythema aggravation,pigmentation,papule increase/area increase,and other gastrointestinal reactions)was counted.Results The total effective rate was 65.00%(13/20)in group A,75.00%(15/20)in group B,and 95.00%(19/20)in group C.The difference was statistically significant(P<0.05);DLQI scores in group C decreased gradually with the course of treatment,and were lower than those in groups A and B at the same period(P<0.05);After treatment,the skin lesion scores of the three groups decreased compared with those before treatment,and group C was better than group A and B(P<0.05);The incidence of adverse reactions in group C was lower than that in groups A and B(P<0.05).Conclusions Both precision light and isotretinoin have shown good effects in the treatment of rosacea,and the combination of the two has better efficacy and high safety,which has a positive effect on improving the quality of life of patients with rosacea and improving the symptoms of skin lesions,and is worthy of clinical application.

关 键 词：酒糟鼻 精准光疗法 异维A酸 疗效分析 

分 类 号：R758.73[医药卫生—皮肤病学与性病学]