RGD在核素显像中对类风湿关节炎评价滑膜新生血管分子显像的研究进展  

Research progress of molecular imaging of synovial neovascularization evaluated by RGD in radionuclide imaging for rheumatoid arthritis

作　　者：闫文荟 王雪梅[1] YAN Wenhui;WANG Xuemei(Department of Nuclear Medicine,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010059,China;Ultrasound medical center,Inner Mongolia International Mongolian Medicine Hospital,Hohhot 010020,China)

机构地区：[1]内蒙古医科大学附属医院核医学科,内蒙古呼和浩特010059 [2]内蒙古国际蒙医医院超声医学中心,内蒙古呼和浩特010020

出　　处：《分子影像学杂志》2024年第9期984-989,共6页Journal of Molecular Imaging

基　　金：国家自然科学基金(81860311)。

摘　　要：滑膜血管翳的形成是类风湿性关节炎的重要病理特征之一,它引起关节软骨和骨的损伤,并导致关节结构重塑,最终可能导致关节畸形和功能障碍。在这个过程中,新生血管对于滑膜血管翳的侵袭和破坏起着至关重要的作用,它增强了血管翳的侵袭性并加速了软骨和骨的损伤。新生血管在类风湿性关节炎早期就开始发挥作用,并贯穿整个疾病进程。新生血管高表达整合素αvβ3,在精氨酸-甘氨酸-天冬氨酸(RGD)上具有高度亲合力。利用分子成像技术来探究类风湿性关节炎中与血管生成相关联分子对于早期检测、评估疾病活动性、选择针对性治疗以及预后评估都具有至关重要意义。本综述将PET和SPECT成像示踪剂根据其靶向αvβ3整合素进行分类,并列举不同类型RGD肽亚基放射性示踪剂与其结合情况,同时比较不同放射性核素标记基于RGD亚基诊断类风湿性关节炎时所带来优缺点。The formation of synovial pannus is one of the important pathological features of rheumatoid arthritis,which triggers articular cartilage and bone injury,leading to joint remodeling,eventual joint deformity and dysfunction.In this process,new angiogenesis plays a crucial role in the invasion and destruction of synovial pannus,enhancing its aggressiveness and accelerating cartilage and bone injury.Neovascularization occurs early in rheumatoid arthritis and persists throughout the course of the disease.Integrin αvβ3 is highly expressed in angiogenesis and has a high affinity for arginine-glycine-aspartate(RGD).Exploring imaging techniques that target angiogenesis in rheumatoid arthritis is significant for early detection,assessment of disease activity,selection of targeted treatment,and prognosis assessment.This review classifies PET and SPECT imaging tracers based on their targeting ofαvβ3 integrins,lists different types of RGD peptide subunit radiotracers,compares the advantages and disadvantages of different radionuclide markers for diagnosing rheumatoid arthritis based on RGD subunits.

关 键 词：类风湿性关节炎 新生血管 核素显像 

分 类 号：R593.22[医药卫生—内科学] R817.4[医药卫生—临床医学]