枳实半夏瓜蒌汤联合心功能康复指导对冠心病稳定性心绞痛的疗效及心电图变化的影响研究  

The Effect of Angina Pectoris and The Effect of ECG Changes

作　　者：李东鑫 LI Dong-xin(First Department of Internal Medicine,Dingnan Second Hospital,Ganzhou 341900,Jiangxi Province,China)

机构地区：[1]赣州市定南第二医院内一科,江西赣州341900

出　　处：《罕少疾病杂志》2024年第9期62-64,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的 探究枳实半夏瓜蒌汤联合心功能康复指导对冠心病稳定性心绞痛的疗效及心电图变化的影响。方法 采用随机数字表法将2021.2-2022.2期间收治的冠心病稳定性心绞痛病人119例分为参照组(n=59,心功能康复指导)和试验组(n=60,枳实半夏瓜蒌汤联合心功能康复指导),对比两组干预效果。结果 试验组总有效率91.67%高于参照组76.27%(P<0.05),研究对象干预前的心功能、炎症因子水平、症状积分、心肌纤维化指标并无差异(P>0.05),干预后,两组左室射血分数(LVEF)均升高,左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)数值、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平、胸痛、心悸不宁、胸闷、倦怠懒言积分、Ⅰ型胶原羧基末端端肽(I CTP)、Ⅰ型胶原前体C前肽(PICP)、Ⅲ型胶原前体的N前肽(PIII NP)水平均下降,其中,除试验组LVEF、PICP/PIII NP较参照组高,余下指标均较低(P<0.05)。结论 将枳实半夏瓜蒌汤联合心功能康复指导应用于冠心病稳定性心绞痛后,疗效确切,能够改善患者心功能及心肌纤维化,防止心肌重塑,促进炎性反应消失,值得应用。Objective To explore the effect of Zhi Shi Ban Xia Gua Lou Tang Combined with Cardiac Function Rehabilitation Guidance on the Efficacy and Electrocardiographic Changes of Stable Angina Pectoris in Patients with Coronary Heart Disease.Methods 119 patients with stable coronary heart disease angina admitted during the period from February 2021 to February 2022 were divided into reference group(n=59,cardiac rehabilitation guidance)and trial group(n=60,and combined with cardiac rehabilitation guidance)to compare the intervention effects of the two groups.Results The total response rate of the test group was 91.67% higher than the reference group of 76.27%(P<0.05),There were no differences in cardiac function,inflammatory factor level,symptom integral,and myocardial fibrosis index before the intervention(P>0.05).After the intervention,left ventricular ejection fraction(LVEF)was increased in both groups,LV end-diastolic diameter(LV EDD),LV end-systolic diameter(LVESD)values,hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor-necrosis factor-α(TNF-α),(TNF-α),chest pain,palpitation,chest tightness,burnout,speech integral,collagen I carboxyl-terminal peptide(ICTP),collagen I collagen precursor C propeptide(PICP),N propeptide(PIII NP)levels,among,Except for higher LVEF,PICP/PIII NP in the test group than the reference group,The remaining indicators were all low(P<0.05).Conclusion The application of Zhi Shi Ban Xia Gua Lou Tang combined with cardiac function rehabilitation guidance to the stability of coronary heart disease,the curative effect is definite,can improve the cardiac function and myocardial fibrosis,prevent myocardial remodeling,promote the disappearance of inflammatory reaction,it is worth applying.

关 键 词：冠心病 枳实半夏瓜蒌汤 心绞痛 心功能康复指导 

分 类 号：R541.4[医药卫生—心血管疾病]