艾滋病合并宫颈病变患者细胞免疫状态及其高危型HPV感染率研究  

Study on Cellular Immune Status and High-risk HPV Infection Rate in Patients with Acquired Immune Deficiency Syndrome and Cervical Lesions

作　　者：李新新 亓露 LI Xin-xin;QI Lu(Obstetrics and Gynecology Department,Henan Infectious Disease Hospital,Zhengzhou 450000,Henan Province,China)

机构地区：[1]河南省传染病医院妇产科,河南郑州450000

出　　处：《罕少疾病杂志》2024年第9期137-138,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的 分析艾滋病(AIDS)合并宫颈病变患者细胞免疫状态及其高危型人类乳头瘤病毒(HPV)感染率。方法 纳入2020年3月~2023年3月期间我院收治的102例AIDS合并宫颈病变患者,根据其宫颈病变类型,分为宫颈癌组(n=32)、宫颈上皮内瘤变(CIN)组(n=44)、宫颈炎组(n=26)。检测并比较三组患者细胞免疫状态[CD4+、CD8+]及高危型HPV感染率。使用受试者工作(ROC)曲线分析CD4+、CD8+水平联合高危型HPV感染率预测AIDS患者合并宫颈癌的预测价值。结果 三组患者CD4+、CD8+水平及高危型HPV感染率比较存在明显差异,CD4+水平比较中,宫颈癌组CIN组>宫颈炎组,差异有统计学意义(P<0.05)。ROC曲线中,CD4+、CD8+水平联合高危型HPV感染率预测AIDS患者合并宫颈癌的曲线下面积(AUC)为0.879,敏感度为71.87%,特异度为94.29%。结论 AIDS患者细胞免疫功能降低及其高危型HPV感染情况会增加宫颈癌发生风险,临床需积极检测患者细胞免疫状态及高危型HPV感染情况,对AIDS患者并发宫颈病变进行预防、早期诊断及治疗。Objective To analyze the cellular immune status and high-risk human papillomavirus(HPV)infection rate in patients with acquired immune deficiency syndrome(AIDS)complicated with cervical lesions.Methods 102 patients with AIDS and cervical lesions admitted to the hospital from March 2020 to March 2023 were included.According to the types of cervical lesions,the patients were divided into cervical cancer group(n=32),cervical intraepithelial neoplasia(CIN)group(n=44)and cervicitis group(n=26).The cellular immune status[CD4+,CD8+]and the infection rate of high-risk HPV were detected and compared among the three groups.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of CD4+,CD8+combined with high-risk HPV infection rate on predicting the cervical cancer in patients with AIDS.Results There were significant differences in the levels of CD4+and CD8+andinfection rate of high-risk HPV among the three groups.Comparison of CD4+level showed cervical cancer group<CIN group<cervicitis group(P<0.05).CD8+and high-risk HPV infection rate revealed cervical cancer group>CIN group>cervicitis group(P<0.05).According to ROC curves,the area under the curve(AUC),sensitivity and specificity of CD4+,CD8+combined with high-risk HPV infection rate on predicting cervical cancer in patients with AIDS were 0.879,71.87%and 94.29%.Conclusion The decreased cellular immune function and high-risk HPV infection in patients with AIDS will increase the risk of cervical cancer.It is necessary to actively detect the cellular immune status and high-risk HPV infection in patients with AIDS,and conduct prevention,early diagnosis and treatment of cervical lesions in patients with AIDS.

关 键 词：艾滋病 宫颈病变 宫颈癌 细胞免疫状态 高危型人类乳头瘤病毒感染率 

分 类 号：R512.91[医药卫生—内科学] R711.74[医药卫生—临床医学] R446.63