本科生综合实验:基于共价有机框架的核壳型固定相的制备及色谱性能评价  

A comprehensive undergraduate experiment:preparation and chromatographic evaluation of a core-shell stationary phase based on a covalent organic framework

作　　者：刘锦 田文锠 吴帆 张秋婷 钟燕辉 林子俺 LIU Jin;TIAN Wenchang;WU Fan;ZHANG Qiuting;ZHONG Yanhui;LIN Zian(Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology,Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety,College of Chemistry,Fuzhou University,Fuzhou 350108,China)

机构地区：[1]福州大学化学学院,食品安全与生物分析教育部重点实验室,福建省食品安全分析与检测重点实验室,福建福州350108

出　　处：《色谱》2024年第10期1006-1012,共7页Chinese Journal of Chromatography

基　　金：国家自然科学基金(22274021);福建省自然科学基金(2022J01535);福建省本科高校教育教学研究项目(FBJG20220268);福州大学本科教育教学研究项目.

摘　　要：在教育部不断推进新课程标准的背景下,本文介绍了一项面向本科生仪器分析课程的综合性教学实验,旨在通过实践提高学生在材料制备和仪器使用方面的技能。该实验通过“一锅法”制备了一种基于共价有机框架的核壳结构固定相材料(SiO_(2)@COF_(TTA-DHTA)),并对其进行了详细的理化表征。随后,采用高效液相色谱技术对该材料的色谱性能进行了评估。整个实验流程包括了材料合成、表征、色谱保留行为研究和色谱分离性能测试。该实验不仅加深了学生对于功能材料性质及其应用的理解,而且提高了他们的实验设计和批判性思维能力。通过理论科学与实验教学的结合,该实验不仅能够培养学生的科研兴趣,还可以锻炼实验操作能力、创新思维和实践能力,同时增强学生的社会责任感和历史使命感,实现实验教学的全方位育人目标。Continuously promoting new curriculum standards is a key aim of the Ministry of Education of China.With this in mind,this paper introduces a comprehensive teaching experiment for undergraduate instrumental analysis courses that aims to improve students’material-preparation and instrumental-analysis skills through practice.Herein,a covalent organic framework-based core-shell stationary phase material(SiO_(2)@COF_(TTA-DHTA))is prepared via a one-pot method and characterized in detail,after which its chromatographic properties are evaluated by high performance liquid chromatography(HPLC).The experimental process includes material synthesis and characterization,as well as studying the chromatographic-retention behavior and chromatographic-separation performance of the material.By the combining theoretical science and experimental teaching,this experiment not only deepens students’understanding of the properties of functional materials and their applications,but also improves their experimental-design and critical-thinking skills.This experiment not only cultivates students’interests in scientific research,but also exercises their experimental,operational,innovative-thinking,and practical abilities,while concurrently enhancing their sense of social responsibility and historical mission,thereby delivering the all-round educational goals of experimental teaching.

关 键 词：综合性实验 共价有机框架 色谱固定相 核壳结构 

分 类 号：O658[理学—分析化学]