血清LTBP-2、COMP水平与ST段抬高型心肌梗死患者病情、预后的关系  

Relationship between serum LTBP-2,COMP levels and the condition,prognosis of patients with ST-segment elevation myocardial infarction

作　　者：付艳华[1] 陈炅[2] 郭华[2] FU Yanhua;CHEN Jiong;GUO Hua(Department of Geriatrics,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Emergency Departent,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第五附属医院老年医学科,河南郑州450052 [2]郑州大学第五附属医院急诊科,河南郑州450052

出　　处：《中国实验诊断学》2024年第9期1045-1049,共5页Chinese Journal of Laboratory Diagnosis

摘　　要：目的分析ST段抬高型心肌梗死(STEMI)患者血清潜在转化生长因子结合蛋白2(LTBP-2)和软骨寡聚基质蛋白(COMP)的表达水平,探讨其与患者的病情及预后的关系。方法以2019年1月至2020年12月郑州大学第五附属医院收治的135例STEMI患者为STEMI组,另外选取135名健康体检人员为对照组,STEMI患者根据出院1年随访中是否出现主要不良心脏事件(MACE)分为MACE组和非MACE组;ELISA法检测血清中LTBP-2和COMP的表达水平;采用Pearson法分析STEMI组患者LTBP-2与COMP表达的相关性;采用多因素logistic回归分析影响STEMI患者术后出现MACE的危险因素。结果与对照组相比,STEMI组患者的LTBP-2、COMP表达水平以及饮酒史、吸烟史的人数升高(P<0.05);Gensini积分≤38分的STEMI患者血清LTBP-2、COMP水平明显低于Gensini积分>38分的患者(P<0.05);Pearson法分析显示,STEMI患者血清中LTBP-2和COMP表达呈正相关(r=0.660,P<0.05);STEMI患者术后出现MACE的例数为30/135(22.22%),MACE组患者中发病时间>6 h,Gensini积分>38分、Killip分级Ⅲ~Ⅳ级比例、支架植入个数、血清LTBP-2与COMP表达水平明显高于非MACE组(P<0.05);多因素logistic回归分析表明,发病时间>6 h、Gensini积分>38分、Killip分级Ⅲ~Ⅳ级、支架植入个数≥3、LTBP-2≥39.36 ng/mL和COMP≥35.73 ng/mL是影响STEMI患者术后出现MACE的危险因素(P<0.05)。结论STEMI患者血清中LTBP-2、COMP的表达水平升高,二者与STEMI患者的病情严重程度及预后密切相关。Objective To analyze the serum expression levels of latent-transforming growth factor beta-binding protein-2(LTBP-2)and cartilage oligomeric matrix protein(COMP)in patients with ST-segment elevation myocardial infarction(STEMI),and to explore their relationship with the condition and prognosis.Methods From January 2019 to December 2020,135 STEMI patients admitted to our hospital were regarded as the STEMI group,another 135 healthy people were regarded as the control group.STEMI patients were grouped into MACE group and non-MACE group according to whether major adverse cardiac events(MACE)occurred during 1-year follow-up after discharge;the expression levels of LTBP-2 and COMP in serum were detected by ELISA;Pearson's method was applied to analyze the correlation between the expression of LTBP-2 and COMP in STEMI group;multivariate logistic regression analysis was applied to analyze the risk factors of postoperative MACE in STEMI patients.Results Compared with the control group,the STEMI group had an increase in LTBP-2 and COMP expression levels,as well as a history of alcohol consumption and smoking(P<0.05);levels of serum LTBP-2 and COMP in STEMI patients with Gensini score≤38 points were obviously lower than those in STEMI patients with Gensini score>38 points(P<0.05);Pearson's method analysis showed that the expression of LTBP-2 and COMP in the serum of STEMI patients was positively correlated(r=0.660,P<0.05);the number of STEMI patients with postoperative MACE was 30/135(22.22%),the onset time>6 h,the Gensini score>38 points,the proportion of Killip gradesⅢtoⅣ,the number of implanted stents,and the expression levels of serum LTBP-2 and COMP in the MACE group were obviously higher than those in the non-MACE group(P<0.05);multivariate logistic regression analysis showed that onset time>6 h,Gensini score>38 points,Killip gradeⅢ~Ⅳ,number of stents≥3,LTBP-2≥39.36 ng/mL and COMP≥35.73 ng/mL were risk factors for postoperative MACE in STEMI patients(P<0.05).Conclusion The expression levels of LTBP-2

关 键 词：LTBP-2 COMP ST段抬高型心肌梗死 主要不良心脏事件 

分 类 号：R542.22[医药卫生—心血管疾病]