微波消融术治疗对非小细胞肺癌患者miR-152、肿瘤标志物及肺功能的影响  

Effect of microwave ablation treatment on miR-152,tumor markers,and lung function in non-small cell lung cancer

作　　者：江春苗[1] 高从荣[1] 裴韶华[1] 岳晖 龙海灯[2] 江银玲[3] JIANG Chun-miao;GAO Cong-rong;PEI Shao-hua;YUE Hui;LONG Hai-deng;JIANG Yin-ling(Department of Thoracic and Cardiac Surgery,the Second People's Hospital of Hefei,Hefei 230011,Anhui,China;Department of Interventional Vascular Pain,the Second People's Hospital of Hefei,Hefei 230011,Anhui,China;Department of Respiratory and Critical Care Medicine,the Second People's Hospital of Hefei,Hefei 230011,Anhui,China)

机构地区：[1]合肥市第二人民医院胸心外科,安徽合肥230011 [2]合肥市第二人民医院介入血管疼痛科,安徽合肥230011 [3]合肥市第二人民医院呼吸与危重症医学科,安徽合肥230011

出　　处：《川北医学院学报》2024年第9期1250-1254,共5页Journal of North Sichuan Medical College

基　　金：安徽医科大学校科研基金立项资助项目(2023xkj230)。

摘　　要：目的:探讨微波消融术对比3D胸腔镜手术治疗对非小细胞肺癌患者miR-152、肿瘤标志物及肺功能的影响。方法:选取82例非小细胞肺癌患者为研究对象,根据接受的治疗方式不同分为对照组及观察组,每组各41例。对照组采用3D胸腔镜手术治疗;观察组采用微波消融术治疗。比较两组患者围术期指标、治疗疗效、肺功能[第1秒用力呼气容积占预计值百分比(FEV1%)及用力肺活量(FVC)]、肿瘤标志物[糖类抗原(CA153)、糖类抗原(CA125)及细胞角蛋白19片段(CYFRA21-1)]、炎症[白细胞介素2(IL-2)及IL-10]、miR-152水平及不良反应发生情况。结果:观察组手术时间、术中出血量、住院时间及住院费用均低于对照组(P<0.05)。治疗后1个月,两组患者FEV1%及FVC水平均降低(P<0.05),但观察组高于对照组(P<0.05);治疗后3个月,两组患者FEV1%及FVC均高于治疗后1个月水平(P<0.05),但两组无统计学差异(P>0.05)。治疗后,两组患者CA153、CA125、CYFRA21-1水平均降低(P<0.05),且观察组低于对照组(P<0.05);两组患者IL-2及miR-152水平均高于治疗前(P<0.05),且观察组高于对照组(P<0.05),两组患者IL-10水平比治疗前降低(P<0.05),且观察组低于对照组(P<0.05)。两组患者不良反应总发生率无统计学差异(P>0.05)。结论:采用微波消融术治疗非小细胞肺癌疗效确切,相较于3D胸腔镜手术治疗,更利于降低患者炎症及肿瘤标志物水平,安全性较好,值得临床推广应用。Objective:To investigate the effects of microwave ablation compared with 3D thoracoscopic surgery for non-small cell lung cancer on miR-152,tumor markers and lung function.Methods:82 cases of non-small cell lung cancer patients were selected as the inclusion subjects,and according to the treatment received by the inclusion subjects,they were divided into the control group and the observation group,41 cases in each group.The control group was treated with 3D thoracoscopic surgery and the observation group was treated with microwave ablation.Perioperative indices,treatment efficacy,lung function[exertional expiratory volume at 1st's as a percentage of predicted value(FEV1%),exertional lung capacity(FVC)],tumor markers[glycoantigen(CA153),glycoconjugate antigen(CA125),cytokeratin 19 fragment(CYFRA21-1)],inflammation[interleukin-2(IL-2),interleukin-10(IL-10)],miR-152,and the incidence of adverse reactions were compared between the two groups.Results:The operation time,intraoperative bleeding,hospitalization time and hospitalization cost of the observation group were lower than those of the control group(P<0.05).At 1 month after treatment,FEV1%and FVC levels were reduced in both groups,and the observation group was higher than the control group(P<0.05).At 3 months after treatment,FEV1%and FVC were higher in both groups than the levels at 1 month after treatment(P<0.05),there was no statistical difference between the two groups(P>0.05).After treatment,CA153,CA125,and CYFRA21-1 in both groups decreased(P<0.05),and the observation group was lower than the control group(P<0.05).The levels of IL-2 and miR-152 were higher than those before treatment,and the observation group was higher than the control group(P<0.05).The IL-10 levels in both groups decreased compared to before treatment(P<0.05),and the observation group was lower than the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:The efficacy of using microwave

关 键 词：微波消融术 胸腔镜 非小细胞肺癌 miR-152 肺功能 

分 类 号：R979.1[医药卫生—药品]