肠道菌群调节软骨代谢及其对骨性关节炎治疗的作用  

Roles of regulating cartilage metabolism by intestinal flora in the treatment of osteoarthritis

作　　者：秦启顺 徐世红[2] 姜朝阳 姜登宸 党泽亮 彭培 王兴盛[2] QIN Qishun;XU Shihong;JIANG Zhaoyang;JIANG Dengchen;DANG ZeLiang;PENG Pei;WANG Xingsheng(Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃省中医院,兰州730050

出　　处：《生命的化学》2024年第8期1338-1346,共9页Chemistry of Life

基　　金：甘肃省科技计划项目(创新基地和人才计划)(21JR7RA681);甘肃省科技计划项目(23YFFA0052);甘肃省科技计划项目(22YF7FA104);甘肃省中医药科研课题(GZKZ-2021-4);兰州市科技计划项目(2023-2-95);甘肃省卫生健康行业科研计划(GSWSQN2023-09)。

摘　　要：本文介绍了骨性关节炎的病理特征与关节软骨代谢的关系,并简述了近年来肠道菌群在骨性关节炎发病与进展中的关键作用。通过回顾近年来肠道菌群与关节软骨代谢之间的相关研究,本文分析了肠道菌群调节关节软骨代谢的潜力,以及其在骨性关节炎治疗中的重要性。本文指出通过调节肠道菌群来治疗骨性关节炎的新思路,并提出了相关领域未来研究的方向,包括深入探索肠道菌群与骨性关节炎之间的具体互作机制,以及开发新的益生菌或预生菌等调节肠道菌群的干预措施,强调了个性化的肠道菌群调节策略的重要性,同时展望了肠道菌群作为调节关节软骨代谢和治疗骨性关节炎的新兴靶点所展现的巨大潜力。This work discusses the pathological characteristics of osteoarthritis in relation to the metabolism of joint cartilage and briefly outlines the key role of the gut microbiota in the onset and progression of osteoarthritis in recent years.By reviewing recent studies on the relationship between the gut microbiota and joint cartilage metabolism,it analyzes the potential of the gut microbiota to regulate cartilage metabolism and its importance in the treatment of osteoarthritis.The work suggests new approaches to treating osteoarthritis by modulating the gut microbiota and proposes directions for future research in this field.It includes a deeper exploration of the specific interactions between the gut microbiota and osteoarthritis,and the development of new probiotics or prebiotics as interventions to modulate the gut microbiota.It emphasizes the importance of personalized gut microbiota modulation strategies and envisions the tremendous potential of the gut microbiota as an emerging target for regulating joint cartilage metabolism and treating osteoarthritis.

关 键 词：骨性关节炎 肠道菌群 软骨代谢 应激 

分 类 号：R684.3[医药卫生—骨科学]