中药复方及有效成分靶向microRNA调控心肌纤维化的研究进展  

Research progress on targeted microRNA regulation of myocardial fibrosis by Chinese herbal compounds and active ingredients

作　　者：王菲 方格 胡思远 胡志希 WANG Fei;FANG Ge;HU Siyuan;HU Zhixi(Department of Traditional Chinese Medicine,the First Affiliated Hospital of University of South China,Hengyang 421001,China;Hunan University of Chinese Medicine,Zhuzhou 412000,China;Hunan College of Chinese Medicine,Changsha 410208,China)

机构地区：[1]南华大学附属第一医院中医科,衡阳421001 [2]湖南中医药大学,株洲412000 [3]湖南中医药高等专科学校,长沙410208

出　　处：《生命的化学》2024年第8期1412-1424,共13页Chemistry of Life

基　　金：国家自然科学基金项目(82274412);湖南省教育厅项目(21A0230);湖南中医药大学校级研究生创新课题项目(2023CX01)。

摘　　要：心肌纤维化以细胞外基质沉积为主要特征,是许多心血管疾病发展到一定阶段的共同病理变化。心肌纤维化过程中的一些微小RNA(microRNA,miRNA)表达异常,并通过对多种信号通路的调控,参与心肌成纤维细胞的活化和增殖过程,从而介导心肌纤维化的发生和发展。本文综述了miRNA在心肌纤维化中的作用和机制,并对中药复方及有效成分靶向miRNA调控心肌纤维化的研究成果进行归纳总结,为心肌纤维化的诊治提供新的思路。Myocardial fibrosis,characterized by extracellular matrix deposition,is a common pathological change in many cardiovascular diseases at a certain stage of development.Some microRNAs are abnormally expressed in the process of myocardial fibrosis,and participate in the activation and proliferation of myocardial fibroblasts through the regulation of a variety of signaling pathways,thus mediating the occurrence and development of myocardial fibrosis.In this paper,the role and mechanism of miRNA in myocardial fibrosis were reviewed,and the research results on the regulation of myocardial fibrosis by targeting microRNA with Chinese herbal compounds and active components were summarized,aiming to provide new ideas for the diagnosis and treatment of myocardial fibrosis.

关 键 词：微小RNA 心肌纤维化 中药复方 中药有效成分 

分 类 号：R285[医药卫生—中药学]