内皮祖细胞在心血管疾病治疗中的作用机制及临床应用前景  

Mechanisms and clinical application prospects of endothelial progenitor cells in the treatment of cardiovascular diseases

作　　者：钟友斌 周倜[1] ZHONG Youbin;ZHOU Ti(Department of Biochemistry and Molecular Biology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]中山大学中山医学院生物化学与分子生物学系,广州510080

出　　处：《生命的化学》2024年第8期1449-1457,共9页Chemistry of Life

基　　金：国家自然科学基金面上项目(82070882);广东省自然科学基金面上项目(2023A1515010316);广东省自然科学基金面上项目(2024A1515012449)。

摘　　要：心血管疾病(cardiovascular diseases,CVD)是引起死亡的重要因素之一,造成了巨大的经济和医疗负担,探索新的治疗方法和策略显得尤为迫切。在当代医学研究中,内皮祖细胞(endothelial progenitor cells,EPCs)因具有修复受损内皮、促进血管生成和调节血管功能的能力,作为一种具有潜在治疗价值的细胞类型备受关注。本文首先介绍EPCs的来源、特性和生物学功能,随后重点综述其在CVD治疗中可能的作用机制。此外,本文还总结了EPCs在临床应用中的挑战与机遇,并展望了其在CVD治疗中的潜在应用前景,以期为未来EPCs治疗疾病的相关研究和临床应用提供一定的理论参考。Cardiovascular diseases(CVD),as a significant factor leading to mortality,impose considerable economic and healthcare burdens,demanding urgent exploration of new treatment methods and strategies.In contemporary medical research,endothelial progenitor cells(EPCs)have garnered significant attention as a cell type with potential therapeutic value,due to their ability to repair damaged endothelium,promote vascular regeneration,and regulate vascular function.This paper firstly introduced the origin,characteristics,and biological functions of EPCs,followed by a focused review of their potential mechanisms of action in CVD treatment.Additionally,we summarized the challenges and opportunities of EPCs in clinical applications,and anticipated their potential prospects in the treatment of CVD,aiming to provide theoretical references for future research and clinical applications of EPCs in disease treatment.

关 键 词：内皮祖细胞 心血管疾病 临床应用 

分 类 号：R54[医药卫生—心血管疾病]