原核非编码小RNA的功能机制与调控网络  

Functions and regulatory networks of non-coding small RNA in prokaryotes

作　　者：刘方[1] 晁彦杰 LIU Fang;CHAO Yanjie(Key Laboratory of RNA Innovation,Science and Engineering,Shanghai Institute of Immunity and Infection,Chinese Academy of Sciences,Shanghai 200031,China)

机构地区：[1]中国科学院上海免疫与感染研究所,核糖核酸功能与应用重点实验室,上海200031

出　　处：《生命的化学》2024年第9期1569-1579,共11页Chemistry of Life

基　　金：国家重点研发计划项目(2022YFE0111800);中国科学院B类先导计划项目(XDB0570000)。

摘　　要：非编码小RNA(non-coding small RNA,sRNA)是原核生物中最重要的一类转录后调节因子,一般通过碱基互补配对调节靶标基因表达。sRNA及其调控的靶标基因构成了一个复杂庞大的调控网络,在微生物的各个生理过程发挥着关键性的调控作用,包括毒力和致病性。本文就原核sRNA的产生和功能机制以及sRNA互作网络的鉴定展开综述,以期为发现新的sRNA并阐明它们的调控功能提供新的研究思路。Non-coding small RNA(sRNA)is one of the most important classes of post-transcriptional regulators in prokaryotes,generally regulating target gene expression through basepairing interactions.sRNA and their target genes constitute a large and complex regulatory network,playing critical regulatory roles in various physiological processes,including virulence and pathogenicity.In this paper,we reviewed the mechanisms of bacterial sRNA biogenesis and function,as well as the identification of sRNA interaction networks,with a view to provide new research ideas for the discovery of new sRNA and elucidation of their regulatory functions.

关 键 词：非编码小RNA HFQ RNA-RNA互作 转录后调控 原核微生物 

分 类 号：Q752[生物学—分子生物学]