核糖核酸疫苗与免疫应答  

Immune response to RNA vaccine

作　　者：卓泽文 孟飞龙 ZHUO Zewen;MENG Feilong(Key Laboratory of RNA Innovation,Science and Engineering,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China)

机构地区：[1]中国科学院分子细胞科学卓越创新中心,上海生物化学与细胞生物学研究所,核糖核酸功能与应用重点实验室,上海200031

出　　处：《生命的化学》2024年第9期1767-1778,共12页Chemistry of Life

基　　金：中国科学院先导项目(XDB0570000)。

摘　　要：核糖核酸(RNA)疫苗技术历经多年发展,在新型冠状病毒感染疫情期间得到飞跃式的发展。针对新型冠状病毒的RNA疫苗产品陆续获批上市或纳入紧急使用。近年来,免疫学家对RNA疫苗诱导机体免疫应答的机制展开了系统研究。本文将简介RNA疫苗的临床应用,总结RNA疫苗的抗原设计、固有免疫与适应性免疫应答、不良反应的免疫机理等,并对RNA疫苗技术尚待解决的问题进行展望。After decades of development,RNA vaccine technology finally took a leap forward during the COVID-19 pandemic.The messenger RNA vaccine products targeting SARS-CoV-2 have been approved for marketing or included in emergency use.In recent years,immunologists have systematically investigated the mechanisms by which RNA vaccines induce a robust immune response.This review will briefly introduce the different types of RNA vaccines,summarize the antigen design,innate and adaptive immune responses,and immune mechanisms of side effects of RNA vaccines,and discuss the problems that need to be solved in RNA vaccine technology.

关 键 词：RNA疫苗 抗原设计 抗体 免疫应答 多系统炎症综合征 

分 类 号：R392[医药卫生—免疫学]