六西格玛DMAIC模型结合中医综合疗法在SAP患者SIRS管理方案中的应用研究  

Application Study on Six Sigma DMAIC Model Combined with Traditional Chinese Medicine Therapy in SIRS Management Scheme for SAP Patients

作　　者：高娅妮 王秀锋 陈嘉屿 于晓辉 马强 朱玥璇 李蔚 GAO Ya'ni;WANG Xiufeng;CHEN Jiayu;YU Xiaohui;MA Qiang;ZHU Yuexuan;LI Wei(Gastroenterology Department,Hospital 940 of PLA Joint Logistics Support Force,Lanzhou 730050,China)

机构地区：[1]联勤保障部队第九四〇医院消化内科,甘肃兰州730050

出　　处：《西部中医药》2024年第9期120-124,共5页Western Journal of Traditional Chinese Medicine

基　　金：甘肃省自然科学基金(22JR5RA015);中国人民解放军联勤保障部队第940医院院内课题(2021yxky073,2023YXKY019)。

摘　　要：目的:探讨以全身炎性反应综合征(systemic inflammatory response syndrome,SIRS)为特征的重症急性胰腺炎(severe acute pancreatitis,SAP)患者应用六西格玛DMAIC模型结合中医综合疗法的临床价值。方法:以确诊为SAP的126例患者为研究对象,采用同期奇、偶数方法分为对照组和六西格玛组各63例,对照组采用西医常规治疗,六西格玛组在对照组基础上采用六西格玛DMAIC模型结合中医综合疗法的SIRS管理方案。观察两组患者血清C反应蛋白(C-reaction protein,CRP)、白细胞介素6(interleukin-6,IL-6)和降钙素原(procalcitonin,PCT)水平以及体温、心率、呼吸、白细胞水平与中医证候积分、临床疗效。结果:与对照组干预后比较,六西格玛组患者血清CRP、IL-6和PCT水平降低(P<0.05),患者体温、心率、呼吸、白细胞水平降低(P<0.05),中医证候(发热、口渴、腹痛、舌苔黄腻及总分)积分降低(P<0.05)。六西格玛组总疗效优于对照组(P<0.05)。结论:六西格玛DMAIC模型结合中医综合疗法能够有效抑制SAP患者炎症反应,改善中医证候,提高临床疗效。Objective:To investigate the clinical values of the six sigma DMAIC(define,measure,analyze,improve,control)model and TCM comprehensive therapy applied in patients with severe acute pancreatitis(SAP)characterized by systemic inflammatory response syndrome(SIRS).Methods:Altogether 126 patients with confirmed SAP were chosen as the objects of study,they were divided into the control group and six sigma group using simultaneous odd and even number,the control group adopted conventional therapy of Western medicine,and six sigma group employed SIRS management scheme containing the six sigma DMAIC model and TCM comprehensive therapy based on the control group.To observe the levels of CRP,IL-6 and PCT,body temperature,heart rate,respiration,the levels of white blood cells(WBC),TCM syndrome integrals and clinical effecs in the two groups.Results:Compared with the control group after the intervention,the levels of CRP,IL-6 and PCT decreased in six sigma group(P<0.05),body temperature,heart rate,respiration,the levels of WBC lowered(P<0.05),TCM syndrome(fever,thirst,abdominal pain,yellow and greasy tongue fur and total scores)integrals reduced(P<0.05).Overall clinical effects of six sigma group were better than these of the control group(P<0.05).Conclusion:The six sigma DMAIC model and TCM comprehensive therapy could effectively inhibit inflammatory response in SAP patients,improve TCM syndromes and enhance clinical effects.

关 键 词：急性胰腺炎 全身炎性反应综合征 六西格玛DMAIC模型 中医综合疗法 应用研究 

分 类 号：R248.1[医药卫生—中医临床基础]