肺力咳合剂联合氧驱雾化特布他林对支气管哮喘患儿肺功能的影响  

Effects of Feilike Mixture combined with oxygen-driven atomized terbutaline on lung function and oxida-tive stress in children with bronchial asthma

作　　者：林晓波 李双 Lin Xiaobo;Li Shuang(Department of Paediatrician,Ninghai Maternal and Child Health Hospital,Ningbo,Zhejiang 315600,China)

机构地区：[1]宁海县妇幼保健院儿科,浙江宁波315600

出　　处：《中国药物与临床》2024年第18期1205-1208,共4页Chinese Remedies & Clinics

摘　　要：目的探讨肺力咳合剂联合氧驱雾化特布他林对支气管哮喘患儿肺功能及氧化应激等指标的影响。方法选取2020年9月至2022年9月浙江省宁海县妇幼保健院收治的150例支气管哮喘患儿,根据治疗方法分为观察组和对照组各75例,对照组患儿给予氧驱雾化特布他林治疗,观察组患儿在对照组的基础上采用肺力咳合剂联合氧驱雾化特布他林治疗,观察对比2组患儿症状改善、白细胞介素水平(IL-6)、肺功能、氧化应激指标水平、治疗满意度及不良反应。结果对照组患儿咳嗽彻底消失时间、哮鸣音消失时间、喘息消失时间分别为(6.98±1.04)d、(7.53±1.21)d、(5.45±1.05)d,观察组患儿分别为(5.27±1.01)d、(4.64±1.15)d、(3.69±1.01)d,差异有统计学意义(P<0.05)。治疗后对照组患儿IL-6表达水平分别为(68±7)g/L,观察组患儿分别为(62±6)g/L,差异有统计学意义(P<0.05)。治疗后对照组患FEV1、PEF、FVC分别为(2.2±0.4)L、(4.1±0.7)L/s、(2.8±0.5)L,观察组患儿分别为(2.6±0.6)L、(5.5±0.8)L/s、(3.6±0.6)L,差异有统计学意义(P<0.05)。对照组治疗满意度89%(67/75),观察组为97%(73/75),差异有统计学意义(P<0.05)。对照组共出现12例(16%)不良反应,其中剧烈咳嗽7例嘴唇发紫3例,治疗终止2例;观察组共出现4例(5%)不良反应,其中剧烈咳嗽2例,嘴唇发紫1例,治疗终止1例,差异有统计学意义(P<0.05)。结论肺力咳合剂联合氧驱雾化特布他林可以快速缓解支气管哮喘患儿的临床症状,改善血清IL-6水平,提升肺功能,调节氧化应激指标、促进患者康复,并提高患儿及家属对治疗的满意度。Objective To explore the effects of Feilike Mixture combined with oxygen-driven atomized terbutaline on lung function and oxidative stress in children with bronchial asthma.Methods A total of 150 children with bronchial asthma admitted to Ninghai Maternal and Child Health Hospital,Ningbo,from September 2020 to September 2022 were selected and divided into an observation group and a control group according to dif-ferent treatment methods,with 75 cases in each group.The control group was treated with oxygen-driven atomized terbutaline,and the observation group was treated with Feilike mixture combined with oxygen-driven atomized terbutaline on the basis of the control group.Symptom improvement,interleukin level(IL-6),lung function,oxida-tive stress index,treatment satisfaction,and adverse reactions were observed and compared between the two groups.Results The total disappearance time of cough,wheezing sound and wheezing in the control group were(6.98±1.04)d,(7.53±1.21)d,and(5.45±1.05)d,respectively;and those in the observation group were(5.27±1.01)d,(4.64±1.15)d,and(3.69±1.01)d,respectively.And the difference between the two groups was statistically sig-nificant(P<0.05).After treatment,the IL-6 levels in the control group and the observation group were(68±7)g/L and(62±6)g/L,respectively,and the difference was statistically significant(P<0.05).After treatment,the FEV1,PEF,and FVC of the control group were(2.2±0.4)L,(4.1±0.7)L/s,and(2.8±0.5)L,respectively,while those in the observation group were(2.6±0.6)L,(5.5±0.8)L/s,and(3.6±0.6)L,respectively.The differences were statisti-cally significant(P<0.05).The treatment satisfaction rates in the control group and the observation group were 89%(67/75)and 97%(73/75)respectively,and the difference was statistically significant(P<0.05).In the control group,there were 12 cases(16%)of adverse reactions,including 7 cases of severe cough,3 cases of purple lips,and 2 cases of treatment termination.In the observation group,there were 4 cases(5%)of adverse reactions,in-

关 键 词：肺力咳合剂 氧驱雾化 特布他林 小儿支气管哮喘 白细胞介素 氧化应激 

分 类 号：R725.6[医药卫生—儿科]