三拗片联合强力枇杷露对感染后咳嗽的疗效与安全性  

Curative effect and safety of San′ao Tablet combined with Qiangli Pipa Syrup in cough after infection

作　　者：徐荣荣 何婷[1] 叶丽静 丁娅 尹章勇 Xu Rongrong;He Ting;Ye Lijing;Ding Ya;Yin Zhangyong(Department of Respiratory Medicine,Lishui People′s Hospital,Lishui,Zhejiang 323000,China)

机构地区：[1]丽水市人民医院呼吸内科,浙江丽水323000

出　　处：《中国药物与临床》2024年第18期1214-1218,共5页Chinese Remedies & Clinics

摘　　要：目的探究三拗片联合强力枇杷露对感染后咳嗽的疗效与安全性。方法回顾性分析2022年1月至2023年12月浙江省丽水市人民医院收治的80例感染后咳嗽患者的临床资料。根据患者接受的不同治疗方案进行分组,将感染后咳嗽常规治疗的患者纳入常规组(37例),将三拗片联合强力枇杷露治疗的患者纳入联合组(43例),2组的治疗周期均为14 d。对比2组的治疗有效率,中医证候积分(咳嗽、气喘、咳痰、肺部音),日间、夜间咳嗽评分,免疫功能[免疫球蛋白(Ig)A、IgG、IgM];炎症水平[肿瘤坏死因子α(TNF-α)、白细胞介素(IL)-6、IL-8];药物不良反应(头晕、嗜睡、恶心呕吐)。结果联合组患者的治疗有效率为93%高于常规组76%(P<0.05);联合组患者的中医证候积分[咳嗽(1.24±0.35)分、气喘(1.17±0.29)分、咳痰(1.01±0.41)分、肺部音(1.33±0.45)分]低于常规组[咳嗽(1.85±0.42)分、气喘(1.74±0.37)分、咳痰(1.76±0.37)分、肺部音(1.69±0.32)分](P<0.05);联合组患者的日间咳嗽评分和夜间咳嗽评分[(0.78±0.21)分和(0.76±0.24)分]均低于常规组[(0.97±0.23)分和(0.91±0.22)分](P<0.05);联合组患者的IgA、IgG、IgM[(1.63±0.24)g/L、(9.65±1.33)g/L、(1.21±0.37)g/L]均高于常规组[(1.27±0.21)g/L、(7.32±1.68)g/L、(0.88±0.25)g/L](P<0.05);联合组患者的TNF-α、IL-6、IL-8水平[(12.6±1.2)pg/ml、(162±8)pg/ml、(9.5±2.8)pg/ml]均低于常规组[(15.4±1.2)pg/ml、(176±10)pg/ml、(11.6±2.6)pg/ml](P<0.05);联合组不良反应发生率为5%低于常规组的22%(P<0.05)。结论三拗片联合强力枇杷露对感染后咳嗽患者的疗效显著,可有效改善患者的咳嗽症状,提高免疫功能,降低炎症反应,且安全性高。Objective To explore the curative effect and safety of San′ao tablet combined with Qiangli Pipa Syrup in cough after infection.Methods A retrospective analysis was performed on the clinical data of 80 patients with cough after infection in Lishui People′s Hospital between January 2022 and December 2023.Ac-cording to different treatment methods,patients were divided into a routine group(37 cases,routine treatment)and a combination group(43 cases,San′ao Tablet combined with Qiangli Pipa Syrup).All patients were treated for 14 d.The response rate of treatment,scores of TCM symptoms(cough,asthma,expectoration,lung rales),daytime and nighttime cough,immune function[immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)],inflammatory factors[tumor necrosis factorα(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8)]and adverse drug reactions(dizziness,drowsiness,nausea and vomiting)were compared between the two groups.Results The re-sponse rate of treatment in combination group was higher than that in the routine group(93%vs 76%,P<0.05).The scores of TCM symptoms(cough,asthma,expectoration,lung rales)in the combination group were lower than those in the routine group[(1.24±0.35)points,(1.17±0.29)points,(1.01±0.41)points,(1.33±0.45)points vs(1.85±0.42)points,(1.74±0.37)points,(1.76±0.37)points,(1.69±0.32)points;P<0.05].The scores of daytime and night-time cough in the combination group were lower than those in the routine group[(0.78±0.21)points,(0.76±0.24)points vs(0.97±0.23)points,(0.91±0.22)points;P<0.05].Levels of IgA,IgG and IgM were higher than those in the routine group[(1.63±0.24)g/L,(9.65±1.33)g/L,(1.21±0.37)g/L vs(1.27±0.21)g/L,(7.32±1.68)g/L,(0.88±0.25)g/L;P<0.05].Levels of TNF-α,IL-6 and IL-8 were lower than those in the routine group[(12.6±1.2)pg/ml,(162±8)pg/ml,(9.5±2.8)pg/ml vs(15.4±1.2)pg/ml,(176±10)pg/ml,(11.6±2.6)pg/ml;P<0.05].The incidence rate of adverse reactions was lower than that in the routine group(5%vs 22%,P<0.05).Conclusion Curative effect of San′ao Ta

关 键 词：咳嗽 三拗片 强力枇杷露 治疗结果 

分 类 号：R511.6[医药卫生—内科学] R441.5[医药卫生—临床医学]