酸碱调节对硫酸钙骨水泥理化性能影响的体外研究  

In vitro study on the effect of acid-base regulation on the physicochemical properties of calcium sulfate bone cement

作　　者：伦登兴[1] 徐丽娜[2] 李思影 李世龙 张伟航 胡永成[3] Lun Dengxing;Xu Lina;Li Siying;Li Shilong;Zhang Weihang;Hu Yongcheng(Department of Bone Oncology,Weifang People's Hospital(the First Affiliated Hospital of Shandong Second Medical University),Weifang 261041,China;Department of Respiratory and Critical Care Medicine,Weifang People's Hospital(the First Affiliated Hospital of Shandong Second Medical University),Weifang 261041,China;Department of Bone and Soft Tissue Oncology,Tianjin hospital,Tianjin 300211,China)

机构地区：[1]潍坊市人民医院(山东第二医科大学第一附属医院)骨肿瘤科,261041 [2]潍坊市人民医院(山东第二医科大学第一附属医院)呼吸与危重症医学科,2610412 [3]天津市天津医院骨与软组织肿瘤科,300211

出　　处：《中华老年骨科与康复电子杂志》2024年第3期125-131,共7页Chinese Journal of Geriatric Orthopaedics and Rehabilitation(Electronic Edition)

基　　金：2023年度山东省医务职工科技创新计划联合立项项目(SDYWZGKCJHLH2023061);2023年度潍坊医学院附属医院科技发展项目(2023FYM013)。

摘　　要：目的探讨碱性碳酸钙对硫酸钙骨水泥的理化性能的影响,为制备适合酸碱度的、可注射性硫酸钙骨水泥提供理论依据。方法按CaCO3在硫酸钙复合物的质量比,分为0%、5%、10%、20%、30%组共5组。充分混合不同含量与外科级硫酸钙制备骨水泥的粉剂。将浓度为3%的甲基纤维素溶液作为骨水泥的液剂。按液固比0.4∶1,混合上述骨水泥的粉剂和液剂,搅拌均匀,形成浆体。根据不同的模具,测量并记录CaCO3/硫酸钙复合物的初凝时间、终凝时间、抗压强度、体外降解率及pH值变化。结果单纯硫酸钙的初凝时间和终凝时间分别为(4.96±0.20)、(5.83±0.12)min。随着CaCO3的含量的增加,初凝时间和终凝时间呈先增长后降低的趋势(F=25.428、P<0.001;F=30.780、P<0.001)。当含量为10%时初凝时间和终凝时间最长[(13.17±1.87)min和(14.22±2.00)min]。单纯硫酸钙的抗压强度为(23.33±6.35)MPa。随CaCO3的含量的增加,抗压强度先增强后降低,当含量为20%,抗压强度最大(27.33±5.86)MPa;但CaCO3对硫酸钙抗压强度的影响无统计学差异(F=1.272,P=0.344)。单纯硫酸钙在降解过程均呈酸性环境(pH=5.32),不同含量碳酸钙均能提高pH值;且当含量10%时,体外降解过程中酸碱度趋于平衡(pH=6.67)。结论碳酸钙能改变硫酸钙骨水泥的理化性能,当含量为10%时,能够提供最佳的凝固时间,给术者操作提供足够的时间;且不影响硫酸钙凝固后的抗压强度;此外,当含量为10%时,体内降解过程中的酸碱度也有利于促进新骨的形成。但含量大于10%,其降解时间较短,仍需添加其他的改性剂。Objective To investigate the effect of basic calcium carbonate on the physical and chem-ical properties of medical grade calcium sulfate,and to provide a theoretical basis for the preparation of in-jectable calcium sulfate bone cement with suitable for pH.Methods According to the mass ratio of CaCO3 in calcium sulfate complex,they were divided into 5 groups:0%,5%,10%,20%and 30%.The powder of bone cement was prepared by fully mixing different contents and surgical grade calcium sulfate.Methylcellu-lose solution with a concentration of 3%was used as the liquid agent of bone cement.According to the liquid-solid ratio of 0.4∶1,the powder and liquid of the bone cement are mixed and stirred evenly to form a slurry.According to different molds,the initial setting time,final setting time,compressive strength,in vitro degra-dation rate and pH value of CaCO3/calcium sulfate composite were measured and recorded.Results The initial setting time and final setting time of calcium sulfate were(4.96±0.20)min and(5.83±0.12)min,re-spectively.With the increase of CaCO3 content,the initial setting time and final setting time increased first and then decreased(F=25.428,P<0.001;F=30.780,P<0.001).When the content was 10%,the initial setting time and final setting time were the longest(13.17±1.87 and 14.22±2.00).The compressive strength of pure calcium sulfate is(23.33±6.35)MPa.With the increase of CaCO3 content,the compressive strength first increases and then decreases.When the content is 20%,the maximum compressive strength is(27.33±5.86)MPa;However,there was no significant difference in the effect of CaCO3 on the compressive strength of calcium sulfate(F=1.272,P=0.344).The degradation process of pure calcium sulfate was in acidic envi-ronment(pH=5.32),and different content of calcium carbonate could increase the pH value;When the con-tent was 10%,the pH tended to balance(pH=6.67).Conclusion Calcium carbonate can change the physical and chemical properties of calcium sulfate bone cement.When the concentration is 10%,it can pr

关 键 词：碳酸钙 硫酸钙 骨水泥成形术 抗压强度 凝固时间 

分 类 号：R318.08[医药卫生—生物医学工程]