单中心纵向追踪调查分析我院麻醉药品使用情况  

Single-center longitudinal survey of use of narcotic medicine in a hospital

作　　者：曹兆流 张鹏驰 王赛甫 刘小华 李梦媛[3] 刘辉 CAO Zhao-liu;ZHANG Peng-chi;WANG Sai-fu;LIU Xiao-hua;LI Meng-yuan;LIU Hui(Nanjing Qixia District Hospital(Qixia Branch of Jiangsu Provincial Hospital),Nanjing 210046;Department of Pharmacy,the First Affiliated Hospital of Nanjing Medical University,Jiangsu Provincial Hospital,Nanjing 210049;Department of Pharmacy,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011)

机构地区：[1]南京市栖霞区医院(江苏省人民医院栖霞分院),南京210046 [2]南京医科大学第一附属医院/江苏省人民医院药学部,南京210049 [3]南京医科大学第二附属医院药学部,南京210011

出　　处：《中南药学》2024年第9期2489-2493,共5页Central South Pharmacy

基　　金：南京药学会-常州四药医院药学科研基金资助课题(项目编号:2021YX024)。

摘　　要：目的评估近五年南京市栖霞区医院(江苏省人民医院栖霞分院)麻醉药品利用情况。方法收集2019—2023年麻醉药品临床使用数据,主要分析四个指标:药物利用指标,即累计DDD值(DDDs);药物价格评价指标,限定日剂量费用(DDDc);B/A值,即药物销售总金额排序(B)与药物利用DDDs值排序(A)的比值;手术量复合增长率。结果随着我院与江苏省人民医院的深度合作,手术量不断提升,手术量复合增长率达22.28%,麻醉药品使用量呈上升趋势,2023年DDDs值为6023.39,是2019年(3031.68)的近两倍,相邻年份仅2020年与2021年之间差异有统计学意义(P<0.01)。DDDc值较高的盐酸羟考酮注射液用量呈下降趋势,瑞芬太尼自2020年开始持续稳定在首位。麻醉药品DDDc值保持稳定,最大值为盐酸羟考酮注射液(641.76),最小值为布桂嗪注射液(5.76)。大部分麻醉药品B/A维持在1左右,五年间变化较小;芬太尼注射液的B/A值由2019年的6.00下降至2023年的2.00,盐酸羟考酮注射液的B/A值由2019年的0.25上升至2023年的0.43。结论我院麻醉药品结构合理,基本可满足临床需求,在临床使用方面总体是规范的。临床医师应权衡患者受益,选择安全、有效、经济的麻醉药品。Objective To evaluate the use of narcotic medicine in Nanjing Qixia District Hospital(Qixia Branch of Jiangsu Province Hospital)in the past five years.Methods The clinical data of narcotic medicine were collected from 2019 to 2023,and four main indicators were analyzed:drug utilization indicator,namely cumulative defined daily doses(DDDs);drug price evaluation indicator,defined daily dose cost(DDDc);and B/A value,total drug sales amount(B)to drug utilization DDDs(A),and compound growth rate of operation volume.Results With the deep cooperation between our hospital and Jiangsu Province Hospital,the number of surgeries continued to improve,and the compound annual growth rate reached 22.28%,and the use of narcotic medicine increased accordingly.The DDDs of 2023 reached 6023.39,nearly twice that of 2019(3031.68).A significant difference was found only between 2020 and 2021(P<0.01).The dosage of oxycodone hydrochloride injection with high DDDc value decreased while remifentanil continued to rank the first place since 2020.The DDDc value of narcotic medicines remained stable,with the maximum value of Oxycodone hydrochloride injection(641.76)and the minimum value of Bucinazine injection(5.76).The B/A of most narcotic medicine maintained around 1,with little change over the five years;the B/A value of Fentanyl injection decreased from 6.00 in 2019 to 2.00 in 2023,while that of Oxycodone hydrochloride injection increased from 0.25 in 2019 to 0.43 in 2023.Conclusion The proportion of narcotic medicine in our hospital is reasonable and can basically meet clinical needs with standardized clinical use.

关 键 词：麻醉药品 药物利用 累计限定日剂量 B/A 

分 类 号：R969.3[医药卫生—药理学] R95[医药卫生—药学]