不同生长时期大黄中无机元素的测定及健康风险评估  

Determination of Inorganic Elements in Rhubarb at Different Growth Periods and Health Risk Assessment

作　　者：王波 王彩虹 祁光增 瞿德业[2] 王新潮 朱梦晨 张航 解迎双 WANG Bo;WANG Caihong;QI Guangzeng;QU Deye;WANG Xinchao;ZHU Mengchen;ZHANG Hang;XIE Yingshuang(Lanzhou Customs Technology Center,Lanzhou,Gansu 730010,China;College of Geography and Environmental Science,Northwest Normal University,Lanzhou,Gansu 730070,China;Li County Spring Pharmaceutical Co.,Longnan,Gansu 742200,China)

机构地区：[1]兰州海关技术中心,兰州730010 [2]西北师范大学地理与环境科学学院,兰州730070 [3]礼县春天药业有限责任公司,甘肃陇南742200

出　　处：《中国无机分析化学》2024年第11期1498-1505,共8页Chinese Journal of Inorganic Analytical Chemistry

基　　金：海关总署科研项目(2023HK028);兰州海关科研项目(LK-2023-005);兰州海关科技计划项目(LK-2022-007)。

摘　　要：为了解甘肃礼县所产大黄中无机元素含量情况,测定大黄中铅、砷、镉、铬、汞、镍、铜、锌、硒、钾、钙、钠、镁、磷和铁等15种无机元素含量,分析元素含量与种植年限的相关性,并对大黄中重金属及有害元素进行健康风险评估。采用微波消解-电感耦合等离子体串联质谱法(ICP-MS/MS)和电感耦合等离子体发射光谱(ICP-OES)法测定大黄样品中无机元素的含量,并进行相关性分析和偏最小二乘判别(OPLS-DA)分析,根据测定结果计算重金属及有害元素的最大耐受量(EDI)、靶标危害系数(THQ)和致癌风险(CR)进行健康评估。88批次大黄样本中Pb、As、Cd、Hg、Cu均未超出2020版《中国药典》规定的限值,相关性分析表明,Pb、As、Cd、Cr、Ni、Cu、Zn、Na、Mg、Fe含量与年份存在显著的相关性;最小二乘判别法分析可以较好地区分礼县不同种植年限的大黄无机元素含量;健康风险评估结果表明,大黄样本总体上是安全的。礼县所产大黄未对使用人群造成健康危害,不存在潜在健康风险。In order to understand the content of inorganic elements in rhubarb produced in Li county,Gansu province,to determine the contents of 15 inorganic elements in rhubarb,including lead,arsenic,cadmium,chromium,mercury,nickel,copper,zinc,selenium,potassium,calcium,sodium,magnesium,phosphorus,and iron,to analyze the correlations between elemental contents and years of planting,and to assess the health risks of heavy metals and harmful elements in rhubarb.Microwave digestion inductively coupled plasma tandem mass spectrometry(ICP-MS/MS) and inductively coupled plasma optical emission spectrometry(ICP-OES) were used to determine the contents of inorganic elements in rhubarb samples,and correlation and partial least squares discrimination(OPLS-DA) analyses were carried out to calculate the maximum tolerances(EDI),target hazard factor(THQ) and carcinogenic risk(CR) were calculated from the determination results for health assessment.Pb,As,Cd,Hg and Cu in 88 batches of rhubarb samples did not exceed the limit values specified in the 2020 edition of the Chinese Pharmacopoeia.Correlation analysis showed that there was a significant correlation between the contents of Pb,As,Cd,Cr,Ni,Cu,Zn,Na,Mg and Fe and the year,the least squares discriminant analysis could better differentiate between rhubarb inorganic element contents of different planting years in Li county.The results of health risk assessment showed that the rhubarb samples were generally safe.The rhubarb produced in Li county does not pose health hazards to the user population,and there is no potential health risk.

关 键 词：大黄 无机元素 风险评估 电感耦合等离子体串联质谱 电感耦合等离子发射光谱 

分 类 号：O657.63[理学—分析化学] S567.19[理学—化学]