拆零药品质量管理实践效果分析  

Practice Effect of Quality Management for Dismounted Drugs

作　　者：李卫平 许汝福 王强 LI Weiping;XU Rufu;WANG Qiang(The Second Affiliated Hospital of Army Medical University,Chongqing,China 400037)

机构地区：[1]中国人民解放军陆军军医大学第二附属医院,重庆400037

出　　处：《中国药业》2024年第19期35-39,共5页China Pharmaceuticals

基　　金：2024年重庆市临床药学重点专科建设项目[渝卫办发〔2023〕69号]。

摘　　要：目的提升拆零药品的质量管理水平,降低拆零药品的用药风险。方法从划分拆零药品管理等级、建立拆零量动态调整及预警机制、分级储存及分类标识、建立使用期限管理制度、制订质量监管细则等方面实施拆零药品质量管理。比较质量管理实施前(2021年1月至10月)和实施后(2022年1月至10月)拆零药品月均近效期品种数占比、月均调整拆零量品种数占比,以及拆零药品的吸潮、变质情况。结果质量管理实施后,月均近效期品种数占比为(1.32±0.85)%,显著低于实施前的(2.47±0.83)%(P=0.007);月均调整拆零量品种数占比为(6.24±2.26)%,显著高于实施前的(2.52±1.98)%(P=0.001);3种拆零药品出现吸潮、变质情况,显著低于实施前的7种(P<0.05)。结论加强拆零药品的质量管理,可有效减少近效期药品的产生,降低拆零药品吸潮、变质的数量,提升拆零药品管理的及时性和可持续性。Objective To improve the quality management level of dismounted drugs,and to reduce the medication risks of dismounted drugs.Methods The quality management of dismounted drugs was implemented by dividing the management levels of dismounted drugs,establishing dynamic adjustment and warning mechanisms for dismounted quantities,standardizing storage and classification labeling,establishing a management system for expiration dates,and formulating quality supervision rules.The monthly average proportion of drug varieties with near expiry date,the proportion of drug varieties with monthly average adjusted dismounted quantity,and the moisture absorption and deterioration of the dismantled drugs before(from January to October 2021)and after the implementation of quality management(from January to October 2022)were compared.Results After the implementation of quality management,the monthly average proportion of drug varieties with near expiry date was(1.32±0.85)%,which was significantly lower than(2.47±0.83)%before the implementation(P=0.007);the proportion of drug varieties with monthly average adjusted dismounted quantity was(6.24±2.26)%,which was significantly higher than(2.52±1.98)%before the implementation(P=0.001);there were three kinds of dismounted drugs showed moisture absorption and deterioration,which was significantly lower than seven kinds of dismounted drugs before the implementation(P<0.05).Conclusion Strengthening the quality management of dismounted drugs can effectively reduce the occurrence of drugs with near expiry date,decrease the amount of moisture absorption and deterioration of dismantled drugs,and improve the timeliness and sustainability of dismounted drugs management.

关 键 词：质量管理 拆零药品 药房管理 

分 类 号：R952[医药卫生—药学]