检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:梁俊晖 苏安宇 杨雅雯 李亚欣 边影彤 邓世森 袁秋虹 王利胜[1] LIANG Junhui;SU Anyu;YANG Yawen;LI Yaxin;BIAN Yingtong;DENG Shisen;YUAN Qiuhong;WANG Lisheng(School of Chinese Materia Medica,Guangzhou University of Chinese Medicine,Guangzhou 510006,China;Faculty of Life Sciences&Medicine,Imperial College London,London SW72AZ,United Kingdom)
机构地区:[1]广州中医药大学中药学院,广州510006 [2]帝国理工学院生命科学与医学学院,伦敦SW72AZ
出 处:《中国药学杂志》2024年第16期1522-1531,共10页Chinese Pharmaceutical Journal
基 金:广州市科技计划项目资助(202206010188);广州中医药大学“双一流”与高水平大学学科协同创新团队培育项目资助(2021xk78)。
摘 要:目的 制备利塞膦酸钠可溶性微针,对其进行表征及预防绝经后骨质疏松症药效评价。方法 通过响应面法优选微针的制备工艺;采用扫描电镜、皮内溶解试验、穿刺试验、皮肤屏障恢复试验与体外透皮试验对所制得微针的外观、溶解性能、机械性能、安全性、透皮特性进行表征;采用卵巢切除骨质疏松症模型大鼠进行药效学评价。结果 经过优选的微针配方为聚乙烯吡咯烷酮-硫酸软骨素(PVP K30-CS)配比为1∶0.86,溶剂占比55%;所得微针具有良好的性状,并展现出与口服给药相似的Ca^(2+)、P^(3+)和碱性磷酸酶(alkaline phosphatase,ALP)水平调节能力,显著提升模型大鼠骨密度并修复其骨微结构。结论 利塞膦酸钠可溶性微针质量稳定、使用方便、药效确切,是干预绝经后骨质疏松症的潜在选项。OBJECTIVE To prepare risedronate sodium(RIS)-loaded dissolving microneedle(DMN) and evaluate its efficacy in preventing postmenopausal osteoporosis.METHODS The preparation process of RIS-DMN was optimized by Box-Behnken design of response surface methodology.The appearance,solubility,mechanical property,safety and transdermal effect of RIS-DMN were characterized by scanning electron microscope,intradermal dissolution test,puncture test,skin barrier recovery test and in vitro permeation test.The pharmacodynamic evaluation of RIS-DMN was performed in ovariectomized osteoporosis model rats.RESULTS The optimal formulation were determined to be 45% for solute(mixed with 1∶0.86 PVP K30 and CS) and 55% for solvent.It was found that the RIS-DMN have good physical characteristics and properties,and showed great effects in regulating the level of Ca~(2+),P~(3+)and alkaline phosphatase(ALP).Meanwhile,the RIS-DMN showed great effects in repairing bone microstructure and improving bone density in ovariectomized osteoporosis model rats,as similar as oral administration.CONCLUSION The RIS-DMN has stable quality,convenient use and precise efficacy,shows great potential in the treatment of postmenopausal osteoporosis.
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.33