Alcohol drinking triggered decrease of oxidative balance score is associated with high all-cause and cardiovascular mortality in hypertensive individuals:findings from NHANES 1999–2014  

作　　者：Yu-Jun ZHANG Jing-Jing SONG Jian-Hao ZHAN Chu-Lin ZHOU Ao LI Mao-Qi WANG Ben-Jie LI Cong-Cong DING Yi-Wei ZHANG Zi-Heng TAN Zai-Hua CHENG Xiao HUANG 

机构地区：[1]Department of Cardiology,the Second Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang,China [2]Huankui Academy,Nanchang University,Nanchang,China [3]School of Ophthalmology and Optometry of Nanchang University,Nanchang,China [4]The Second Clinical Medical College,Nanchang University,Nanchang,China [5]Queen Mary School,Nanchang University,Nanchang,China [6]The First Clinical Medical College,Nanchang University,Nanchang,China [7]Department of Cardiovascular Medicine,Huzhou First People’s Hospital,Zhejiang,China

出　　处：《Journal of Geriatric Cardiology》2024年第8期779-790,共12页老年心脏病学杂志（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81960074);the Natural Science Foundation-Outstanding Youth Fund Project of Jiangxi Province(No.20232ACB216006)。

摘　　要：BACKGROUND Oxidative stress is closely associated with hypertensive outcomes.The oxidative balance score(OBS)measures oxidative stress exposure from dietary and lifestyle elements.The objective of this study was to investigate the association between OBS and mortality in hypertensive patients.METHODS This study included 7823 hypertensive patients from the National Health and Nutrition Examination Survey(NHA-NES)1999-2014.Several models,including Cox regression,restricted cubic splines(RCS),Kaplan-Meier survival analysis,subgroup,and sensitivity analyses,were exploited to investigate the relationship between OBS and the risk of mortality.RESULTS Controlling for all potential confounders,a significantly inverse association was observed between elevated OBS and all-cause[hazard ratio(HR)=0.90,95%CI:0.85-0.95]and cardiovascular mortality(HR=0.85,95%CI:0.75-0.95).With adjustment for covariates,significant associations between lifestyle OBS and mortality risks diminished,whereas associations between dietary OBS and these mortality risks remained robust(all-cause mortality:HR=0.91,95%CI:0.86-0.96;cardiovascular mortality:HR=0.85,95%CI:0.76-0.96).RCS demonstrated a linear relationship between OBS and all-cause and cardiovascular mortality risk(P_(nonlinear)=0.088 and P_(nonlinear)=0.447,respectively).Kaplan-Meier curves demonstrated that the mortality rate was lower with a high OBS(P<0.001).The consistency of the association was demonstrated in subgroup and sensitivity analyses.RCS after stratification showed that among current drinkers,those with higher OBS had a lower risk of mortality compared with former or never drinkers.CONCLUSIONS In hypertensive individuals,there was a negative association between OBS and all-cause and cardiovascular mortality.Encouraging hypertensive individuals,especially those currently drinking,to maintain high levels of OBS may be beneficial in improving their prognosis.

关 键 词：HIGH finding Alcohol 

分 类 号：R544.1[医药卫生—心血管疾病]