组织工程技术在阴道重建中的应用及进展  

Application and progress of tissue engineering technology in vaginal reconstruction

作　　者：张雪梅 夏蕾[1,2] 杜彦芳 黄向华[1,2,4] Zhang Xuemei;Xia Lei;Du Yanfang;Huang Xianghua(The Second Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei,China;Hebei Key Laboratory of Regenerative Medicine of Obstetrics and Gynecology,Shijiazhuang 050000,Hebei,China;Cangzhou Central Hospital,Cangzhou 061600,Hebei,China;Hebei Branch of National Clinical Medical Research Center for Obstetrics and Gynecology Diseases,Shijiazhuang 050000,Hebei,China)

机构地区：[1]河北医科大学第二医院,河北石家庄050000 [2]河北省妇产科再生医学重点实验室,河北石家庄050000 [3]沧州市中心医院,河北沧州061600 [4]国家妇产疾病临床医学研究中心河北省分中心,河北石家庄050000

出　　处：《生物医学转化》2024年第3期20-29,共10页Biomedical Transformation

基　　金：河北省自然科学基金项目(H2024206433);中央引导地方科技发展资金项目-科技创新基地项目(236Z7756G);河北省政府资助临床医学优秀人才培养项目。

摘　　要：阴道缺损对患者造成的身心压力巨大,传统的阴道重建方法能在一定程度上恢复生理功能,但往往伴随着长治疗周期和多种并发症。随着组织工程技术的进步,其在阴道重建领域的应用展现出了解决女性生殖系统缺损的优势和潜能。本文分析了近年来组织工程在阴道重建领域的研究进展,探究种子细胞、生物材料、信号因子和动物模型的应用前景,以期为临床阴道修复提供启发和参考。Vaginal defects cause immense physical and psychological stress to patients.Traditional vaginal reconstruction methods can partially restore physiological function but are often associated with long treatment periods and complications.With the advancement of tissue engineering technology,its application in vaginal reconstruction has shown significant advantages and potential in addressing female reproductive system defects.This article analyzes recent research progress in the field of tissue engineering for vaginal reconstruction,exploring the prospects of seed cells,biomaterials,signaling factors,and animal models to provide inspiration and references for clinical vaginal repair.

关 键 词：组织工程 阴道重建 种子细胞 生物材料 信号因子 动物模型 

分 类 号：R713.3[医药卫生—妇产科学]