微粒口腔黏膜代阴道成形术临床应用效果评价  

Evaluation of the clinical outcome of microparticle oral mucosa vaginoplasty

作　　者：张彦骅[1] 王惠玲[1] 刘慧民[1] 杨萍 刘青[1] Zhang Yanhua;Wang Huiling;Liu Huimin;Yang Ping;Liu Qing(Gansu Provincial Maternal and Child-Care Hospital,Lanzhou 730050,Gansu,China;Guangzhou Zixin Plastic Surgery Hospital,Guangzhou 510627,Guangdong,China)

机构地区：[1]甘肃省妇幼保健院,甘肃兰州730050 [2]广州紫馨整形外科医院,广东广州510627

出　　处：《生物医学转化》2024年第3期30-35,共6页Biomedical Transformation

基　　金：兰州市科技计划项目(2022-3-14)。

摘　　要：目的探讨微粒口腔黏膜代阴道成形术的临床应用效果。方法回顾性分析2013年2月-2024年1月甘肃省妇幼保健院收治的149例生殖道畸形(MRKH综合征和阴道闭锁)需要行阴道成形术的患者临床资料。按照手术方式不同分为口腔黏膜代阴道成形术组(n=95)、腹膜代阴道成形术组(n=31),及生物补片代阴道成形术组(n=23),比较手术相关指标、人工阴道相关指标、性生活指标,评价微粒口腔黏膜代阴道成形术的临床应用效果。结果口腔黏膜组及生物补片组在手术时间、出血量方面显著优于腹膜组(P<0.05)。在住院费用上,生物补片组明显高于另外两组,口腔黏膜组花费最低(P<0.05)。术后阴道长度口腔黏膜组及生物补片组优于腹膜组(P<0.05)。阴道弹性、阴道pH值、性满意度、并发症率等指标3组间差异无统计学意义。结论口腔黏膜代阴道成形术简单、微创、无痛。符合患者隐私需求,效果满意,医疗费用低,性价比高,具有临床应用价值。Objective To explore the clinical effectiveness of microparticle oral mucosa vaginoplasty.Methods A retrospective analysis was conducted on the clinical data of 149 patients with reproductive tract malformation(MRKH syndrome and vaginal atresia)who required vaginoplasty and were treated at Gansu Provincial Maternal and Child-Care Hospital from February 2013 to January 2024.Patients were divided into three groups based on the surgical method:oral mucosa vaginoplasty group(n=95),peritoneal vaginoplasty group(n=31),and biological patch vaginoplasty group(n=23).Surgical-related indicators,artificial vagina-related indicators,and sexual function indicators were compared to evaluate the clinical effectiveness of microparticle oral mucosa vaginoplasty.Results The oral mucosa group and the biological patch group demonstrated significantly better outcomes in terms of operation time and blood loss compared to the peritoneal group(P<0.05).Regarding hospitalization costs,the biological patch group had significantly higher expenses than the other two groups,with the oral mucosa group having the lowest costs(P<0.05).Postoperative vaginal length in oral mucosa group and biological patch group was superior to that in the peritoneal group(P<0.05).There were no statistically significant differences among the three groups concerning vaginal elasticity,vaginal pH value,sexual satisfaction,and complication rates.Conclusion Oral mucosa vaginoplasty is a simple,minimally invasive,painless procedure that meets patient privacy needs,with satisfactory outcomes,low medical costs,and high cost-effectiveness,making it clinically valuable.

关 键 词：生殖道畸形 阴道成形术 微粒口腔黏膜 腹膜 生物补片 

分 类 号：R711.1[医药卫生—妇产科学]