腹腔镜腹膜阴道成形术治疗MRKH综合征的临床疗效  

Clinical efficacy of laparoscopic peritoneal vaginoplasty in the treatment of MRKH syndrome

作　　者：秦成路[1] 石瑾秋[1] 姜莉萍 王惠子 梁茂连 马莉莉 任俊旭 黎雪茹 张龙惠 李朦 Qin Chenglu;Shi Jinqiu;Jiang Liping;Wang Huizi;Liang Maolian;Ma Lili;Ren Junxu;Li Xueru;Zhang Longhui;Li Meng(The Third Affiliated Hospital of Shenzhen University(Shenzhen Luohu District People's Hospital),Shenzhen 518000,Guangdong,China)

机构地区：[1]深圳大学第三附属医院(深圳市罗湖区人民医院),广东深圳518000

出　　处：《生物医学转化》2024年第3期36-40,共5页Biomedical Transformation

基　　金：国家重点研发计划重点专项项目(2021YFC2701400)。

摘　　要：目的探讨腹腔镜腹膜阴道成形术(罗湖二式)治疗苗勒管发育不全(MRKH)综合征的临床疗效。方法回顾性分析2020年1月-2024年4月深圳大学附属第三医院(深圳市罗湖区人民医院)诊治的221例MRKH综合征患者的临床资料。患者年龄17~35岁,平均22±8岁,所有患者均采用腹腔镜腹膜阴道成形术(罗湖二式)治疗,分析患者的手术时间、住院时间、术中出血量和术后临床疗效。结果本组221例患者均成功完成腹腔镜腹膜阴道成形术,手术时间25-100 min,平均35±23 min,住院时间15-29 d,平均20±5 d,术中出血量10~100 mL。术前阴道压迹0.5~3.0 cm,术后患者阴道深度10±2 cm,两者差异有统计学意义(P<0.05)。221例患者均顺利完成手术,术后恢复良好,其中1例患者出现膀胱损伤,1例出现直肠损伤,均全部一期缝合修复。所有患者均获得随访,随访时间1-37个月。结论腹腔镜腹膜阴道成形术(罗湖二式)治疗MRKH综合征所致先天性无阴道具有创伤小、恢复快、疗效确切和并发症少等优点,是一种可靠有效的手术方式。Objective To investigate the clinical efficacy of laparoscopic peritoneal vaginoplasty(Luohu Type II)in the treatment of Mayer-Rokitansky-Küster-Hauser(MRKH)syndrome.Methods A retrospective analysis was conducted on the clinical data of 221 patients with MRKH syndrome treated at the Third Affiliated Hospital of Shenzhen University(Shenzhen Luohu People's Hospital)between January 2020 and April 2024.The patients were aged between 17 and 35 years,with an average age of(22±8)years.All patients underwent laparoscopic peritoneal vaginoplasty(Luohu Type II).Surgical time,hospital stay,intraoperative blood loss,and postoperative clinical outcomes were analyzed.Results All 221 patients in this group successfully underwent laparoscopic peritoneal vaginoplasty.The surgical time ranged from 25 to 100 minutes,with an average of(35±23)minutes.The hospital stay ranged from 15 to 29 days,with an average of(20±5)days.Intraoperative blood loss was between 10 and 100 mL.The preoperative vaginal indentation depth was 0.5 to 3 cm,and postoperative vaginal depth was(10±2)cm.The difference was statistically significant(P<0.05).All 221 patients successfully completed surgery and recovered well postoperatively.One patient experienced bladder injury and one patient had rectal injury,both of which were repaired with primary sutures.All patients were followed up for 1 to 37 months.Conclusion Laparoscopic peritoneal vaginoplasty(Luohu TypeⅡ)is a reliable and effective surgical technique for the treatment of congenital absence of the vagina caused by MRKH syndrome,offering advantages such as minimal trauma,quick recovery,definite efficacy,and low complication rates.

关 键 词：MRKH综合征 先天性无阴道 腹腔镜 腹膜阴道成形术 

分 类 号：R711.1[医药卫生—妇产科学]