2017—2022年云南曲靖地区男性HPV感染状况及亚型分布特征  

Prevalence of HPV infection and subtypes among male population in Qujing,Yunnan Province from 2017 to 2022

作　　者：胡建鹏 赵垭钤 李云 刘红霞 邹玉明 耿奇 熊倩 杨春菊 HU Jian-peng;ZHAO Ya-qian;LI Yun;LIU Hong-xia;ZOU Yu-ming;GENG Qi;XIONG Qian;YANG Chun-ju(The First People's Hospital of Qujing City,Qujing,Yunan 655000,China;不详)

机构地区：[1]曲靖市第一人民医院检验中心,云南曲靖655000 [2]曲靖市第一人民医院麻醉科,云南曲靖655000 [3]曲靖医学高等专科学校基础医学院,云南曲靖655100

出　　处：《中华医院感染学杂志》2024年第17期2656-2661,共6页Chinese Journal of Nosocomiology

基　　金：云南省教育厅科学研究基金项目(2024J0152;2020J0800);曲靖市第一人民医院院级课题(2022YJKTY11)。

摘　　要：目的分析云南曲靖地区男性人乳头瘤病毒(HPV)感染状况及亚型特征,为男性HPV的治疗、疫苗的选择与研发以及免疫规划政策决策提供依据。方法收集2017年1月-2022年12月于曲靖市第一人民医院行HPV分型检测的1820例男性患者检测结果,分析该地区男性HPV感染状况及亚型分布特征。结果在1820例患者中检出HPV阳性感染者935例,总体感染率为51.37%,其中发生单一、双重、三重和四重及以上感染的比例分别为37.53%、9.62%、2.58%和1.65%;受检的27种亚型中,检出率最高5种低危型HPV分别为HPV6、11、43、61和55型,分别为25.93%、20.88%、1.92%、1.65%和1.10%,检出率最高5种高危型HPV分别为HPV16、59、52、18和58型,分别为2.58%、2.09%、1.59%、1.48%和1.48%;总体而言,曲靖地区男性单纯低危、单纯高危和高低危混合感染比例分别为74.33%、6.74%和18.93%;感染年龄特异性呈双峰“U”分布。结论曲靖地区男性HPV感染以HPV6、11、43、16、59型最常见,>59岁组和≤19岁组感染率最高,总体表现为感染率高且易多重感染,以低危型感染为主,二价疫苗覆盖率低。OBJECTIVE To investigate the prevalence of human papillomavirus(HPV)infection and genotypes of HPV among the male population in Qujing,Yunnan Province so as to provide bases for treatment of the male with HPV infection,selection and development of vaccine and decision of policies for immunization program.METHODS Totally 1820 male patients who received HPV genotyping in the First People′s Hospital of Qujing City from Jan 2017 to Dec 2022 were enrolled in the study,and the prevalence of HPV infection and genotypes among the male patients were analyzed based on the genotyping result.RESULTS Totally 935 patients were tested positive for HPV infection among the 1820 patients,with the total infection rate 51.37%.The patients with single,double,triple and quadruple or above HPV genotypes infection accounted for 37.53%,9.62%,2.38%and 1.65%,respectively.Among the 27 genotypes tested,HPV6,HPV11,HPV43,HPV61 and HPV55 ranked the top 5 low-risk HPV genotypes,the positive rates were 25.93%,20.88%,1.92%,1.65%and 1.10%,respectively;HPV16,HPV59,HPV52,HPV18 and HPV58 ranked the top 5 high-risk genotypes,and the positive rates were 2.58%,2.09%,1.59%,1.48%and 1.48%,respectively.In general,the proportion of pure LR-HPV,pure HR-HPV and mixed infections were 74.33%,6.74%and 18.93%,respectively.The age specificity of the male population with infection showed a bimodal′U′distribution.CONCLUSION The HPV6,HPV11,HPV43,HPV16 and HPV59 are the most common genotypes among the male population with HPV infection in Qujing area.The infection rates were the highest among the patients with more than 59 years of age and the patients no more than 19 years of age.The population is generally characterized with high infection rate and tends to have multiple infections,and it is dominated by the low-risk HPV infection,and the coverage rate of bivalent vaccine is low.

关 键 词：人乳头瘤病毒 男性 尖锐湿疣 基因型 曲靖地区 流行病学 人乳头瘤病毒疫苗 

分 类 号：R373[医药卫生—病原生物学]