25(OH)D和PDCD5诊断肺炎支原体肺炎患儿合并心肌损伤的临床价值  

Clinical value of 25(OH)D and PDCD5 in diagnosis of concurrent myocardial injury in children with Mycoplasma pneumoniae pneumonia

作　　者：刘浩川 缪爱梅 LIU Hao-chuan;MIAO Ai-mei(Suzhou Municipal Hospital Affiliated to Nanjing Medical University,Suzhou,Jiangsu 215002,China)

机构地区：[1]南京医科大学附属苏州医院苏州市立医院儿科,江苏苏州215002

出　　处：《中华医院感染学杂志》2024年第17期2677-2681,共5页Chinese Journal of Nosocomiology

基　　金：江苏省自然科学基金面上项目(BK20211008)。

摘　　要：目的探讨血清25-羟维生素D[25(OH)D]联合程序化细胞死亡因子5(PDCD5)对肺炎支原体肺炎(MPP)患儿合并心肌损伤的预测价值。方法选取2021年11月-2023年8月南京医科大学附属苏州医院接收的94例MPP患儿为研究对象,其中心肌损伤组35例,非心肌损伤组59例,另选取同一时期在医院接受体检的50名健康儿童为对照组。收集三组研究对象的一般资料,并测定其25(OH)D、PDCD5、心肌酶指标、炎症指标、免疫功能指标表达水平,采用受试者工作特征(ROC)曲线分析25(OH)D和PDCD5对MPP患儿合并心肌损伤的诊断价值。结果三组25(OH)D、PDCD5、心肌酶指标、炎症指标、免疫功能指标表达水平比较,具有统计学差异(P<0.05);心肌损伤组25(OH)D水平更低(P<0.05),PDCD5水平更高(P<0.05);心肌酶指标天门冬氨酸氨基转移酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)和肌酸激酶同工酶(CK-MB)表达水平更高(P<0.05);炎症指标白细胞介素(IL)-6、IL-8和肿瘤坏死因子-α(TNF-α)表达水平更高(P<0.05);免疫功能指标自然杀伤细胞(NK)、白细胞分化抗原簇(CD_(4)^(+))和CD_(4)^(+)/CD_(8)^(+)表达水平更低(P<0.05);ROC曲线结果表明,25(OH)D和PDCD5联合检测对心肌损伤评估的曲线下面积(AUC)值达到0.953。结论MPP患儿合并心肌损伤会导致免疫功能下降和炎症反应增强,25(OH)D和PDCD5表达水平对MPP患儿合并心肌损伤具有较高的预测价值。OBJECTIVE To explore the value of serum 25-hydroxyvitamin D[25(OH)D]combined with programmed cell death 5(PDCD5)in prediction of concurrent myocardial injury in the children with Mycoplasma pneumoniae pneumonia(MPP).METHODS A total of 94 children with MPP who were treated in Suzhou Municipal Hospital Affiliated to Nanjing Medical University from Nov 2021 to Aug 2023 were recruited as the research subjects and were divided into the myocardial injury group with 35 cases and the non-myocardial injury group with 59 cases.Meanwhile,50 healthy children who received physical examination were chosen as the control group.The baseline data were collected from the three groups of subjects.The expression levels of 25(OH)D,PDCD5,myocardial enzyme indexes,inflammation indexes and immune function indexes were detected,and the value of 25(OH)D and PDCD5 in diagnosis of the MMP children complicated with myocardial injury was analyzed by means of receiver operating characteristic(ROC)curves.RESULTS There were significant differences in the expression levels of 25(OH)D,PDCD5,myocardial enzyme indexes,inflammation indexes and immune function indexes among three groups(P<0.05);the 25(OH)D level of the myocardial injury group was the lowest,with the PDCD5 the highest(P<0.05);the expression levels of myocardial enzyme indexes aspartate aminotransferase(AST),lactate dehydrogenase(LDH),creatine kinase(CK)and creatine kinase MB(CK-MB)of the myocardial injury group were the highest(P<0.05);the expression levels of inflammatory indexes interleukin(IL)-6,IL-8 and tumor necrosis factor-α(TNF-α)were the highest(P<0.05);the expression levels of immune function indexes natural killer(NK)cells,cluster of differentiation 4(CD_(4)^(+))and CD_(4)^(+)/CD_(8)^(+)of the myocardial injury group were the lowest(P<0.05).ROC curve analysis showed that the area under curve(AUC)of 25(OH)D combined with PDCD5 was 0.953 in assessment of myocardial injury.CONCLUSION The concurrent myocardial injury may lead to the decline of immune function and enhancement of

关 键 词：血清25-羟维生素D 程序化细胞死亡因子 肺炎支原体肺炎 心肌损伤 诊断价值 

分 类 号：R725.6[医药卫生—儿科]