艾滋病合并恶性肿瘤研究进展  

Progress of research on AIDS complicated with malignant tumors

作　　者：罗琳琳 姜琦 胡新宁 张欣欣[1,2] 李心心 许前磊[1,2,3] LUO Lin-lin;JIANG Qi;HU Xin-ning;ZHANG Xin-xin;LI Xin-xin;XU Qian-lei(The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan 450000,China;不详)

机构地区：[1]河南中医药大学第一附属医院艾滋病临床研究中心,河南郑州450000 [2]河南中医药大学,河南郑州450046 [3]河南省病毒性疾病中医药防治重点实验室,河南郑州450000

出　　处：《中华医院感染学杂志》2024年第17期2715-2720,共6页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金项目(82274474,81873187);中原英才计划基金项目(ZYYCYU202012153);河南省自然科学基金项目(222300420059);河南省科技研发计划联合基金(232301420089);河南省中医药科学研究专项课题(2022ZY1032)。

摘　　要：人类免疫缺陷病毒(HIV)感染者的预期寿命随着抗反转录病毒治疗(ART)的广泛应用不断延长。然而,病毒感染所导致的机体免疫抑制状态使得HIV感染者恶性肿瘤发生率远高于普通人群,成为当前亟待解决的问题。本文旨在通过梳理国内外艾滋病合并恶性肿瘤的流行病学情况,总结不同地区的发病状况,系统阐述艾滋病合并恶性肿瘤的发病机制,包括病毒感染、免疫激活与炎症反应、炎症介质等方面,探讨艾滋病合并恶性肿瘤的治疗现状与挑战,为该病的预防、治疗等方面提供多角度借鉴。The widespread use of anti-retroviral therapy(ART)constantly extends the life expectancy of people living with human immunodeficiency virus(HIV)infection.However,the immunosuppressive state caused by viral infection makes the higher incidence of malignant tumors among the people with HIV infection than among the common population and is urgent to be solved.The article aims to sort out the epidemiological characteristics of complication with malignant tumors among the population with AIDS in China and abroad and summarize the prevalence among the population in different regions.Besides,it also systematically interprets the pathogenesis of malignant tumors in the AIDS population,including viral infection,immune activation and inflammatory mediators,The article also explores the current status of treatment of AIDS population complicated with malignant tumors so as to provide multi-angle reference for prevention and treatment of the disease.

关 键 词：艾滋病 人类免疫缺陷病毒感染 反转录病毒治疗 恶性肿瘤 研究进展 

分 类 号：R512.91[医药卫生—内科学]