基于“毒损脑络”理论探讨黄连改善卒中后认知功能障碍的研究  

Exploring Post-Stroke Cognitive Function and The Application of Huanglian(Coptidis Rhizoma)Based on Theory of“Toxin Damaging Brain Collaterals”

作　　者：孙秀业[1] 杨芳[1] SUN Xiuye;YANG Fang(The Second Affiliated Hospital of Liaoning University of Trational Chinese Medicine,Shenyang 110034,Liaoning,China)

机构地区：[1]辽宁中医药大学附属第二医院,辽宁沈阳110034

出　　处：《中华中医药学刊》2024年第10期32-35,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81874372);辽宁省科技厅联合基金项目面上资助计划项目(2023-MSLH-146);辽宁省自然科学基金(2024-MS-262);辽宁省教育厅项目(L202034);殷晓莉名中医工作室项目(辽中医药发[2022]1号)。

摘　　要：中医学认为,卒中后认知功能障碍(PSCI)病位在脑,“毒损脑络”为PSCI病因病机。从“毒损脑络”角度出发,阐述“毒邪”理论与卒中后认知功能的相关性。并以“解毒通络”为着手点,针对“热毒”“糖毒”“脂毒”“瘀毒”,分别探讨“毒邪”致PSCI的病机,逐步验证“毒损脑络”学说为PSCI的病因病机,为PSCI的中医诊疗提供思路。梳理解毒中药黄连改善认知障碍的文献记载,探析其理论内涵,开拓黄连临证辨证思路,提高解毒中药改善认知障碍的认识。Traditional Chinese medicine(TCM)believes that post-stroke cognitive function(PSCI)is located in the brain,and“toxin damaging brain collaterals”is the etiology and pathogenesis.This article explained the correlation between“toxin”theory and PSCI from the perspective of“toxin damage brain collaterals”.Starting from the perspective of“detoxifying and unblocking the meridians”,this study explored the pathogenesis of PSCI caused by“toxin evil”in relation to“heat toxin”,“sugar toxin”,“lipid toxin”and“blood stasis toxin”,gradually verifying that the theory of“toxin damaging brain collaterals”is the etiology and pathogenesis of PSCI and providing ideas for the traditional Chinese medicine diagnosis and treatment of PSCI.It reviewed the literature records of Huanglian(Coptidis Rhizoma)treating PSCI,explored the theoretical connotation,enriched the clinical application of Huanglian(Coptidis Rhizoma),improved the understanding of Chinese drugs for detoxifying to improve PSCI.

关 键 词：毒损脑络 卒中后认知功能障碍 黄连 

分 类 号：R277.749.13[医药卫生—中医学]