固本解毒祛瘀法与化疗联合治疗晚期非小细胞肺癌的临床研究  

Clinical Study on Treatment of Advanced Non-Small Cell Lung Cancer by Combination of Consolidating Root,Removing Toxin and Dispelling Blood Stasis Method and Chemotherapy

作　　者：许斌 李文婷[2,3] 李丽 刘丹 王羽超 XU Bin;LI Wenting;LI Li;LIU Dan;WANG Yuchao(Affiliated Brain Hospital of Nanjing Medical University(Nanjing Chest Hospital),Nanjing 210029,Jiangsu,China;The First Clinical Medical College,Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China;Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine(TCM)Prevention and Treatment of Tumor,Nanjing 210029,Jiangsu,China)

机构地区：[1]南京医科大学附属脑科医院(胸科院区),江苏南京210029 [2]南京中医药大学第一临床医学院,江苏南京210029 [3]江苏省中医药防治肿瘤协同创新中心,岐黄学者吴勉华工作室,江苏南京210029

出　　处：《中华中医药学刊》2024年第10期48-51,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者项目(国中医药人教函[2018]284号)。

摘　　要：目的研究固本解毒祛瘀法与化疗联合治疗晚期非小细胞肺癌的临床研究。方法选取南京医科大学附属脑科医院(胸科院区)呼吸内科102例被确诊为晚期非小细胞肺癌的患者按随机数字表分为两组,对照组51例予以化疗,研究组51例使用固本解毒祛瘀法、化疗联合治疗。观察比较两组患者的临床疗效。结果研究组客观缓解率与对照组相比,96.08%(49/51)高于对照组74.51%(38/51),差异有统计学意义(P<0.05)。治疗后,研究组与对照组CEA、CA125以及CYFRA21-1对比,研究组低于对照组,研究组与对照组CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)对比,研究组CD_(3)^(+)、CD_(4)^(+)高于对照组,CD_(8)^(+)低于对照组,差异有统计学意义(P<0.05)。研究组胃肠道、肝功损害、血细胞不良反应程度低于对照组,差异有统计学意义(P<0.05)。结论被确诊为强迫症的患者通过服用氯丙咪嗪、温胆汤联合治疗后,临床作用显著,可有效改善患者的临床症状,且安全性较高,临床应用价值较高。Objective To study the clinical study of the treatment of advanced non-small cell lung cancer with the combination of consolidating root,removing toxin and dispelling blood stasis method and chemotherapy.Methods A total of 102 patients diagnosed as advanced non-small cell lung cancer were divided into two groups according to the random number table.Fifty-one patients in the control group were treated with chemotherapy,and the other 51 patients in the study group were treated with consolidating root,removing toxin and dispelling blood stasis method and chemotherapy.The clinical efficacy of the two groups was observed and compared.Results Compared with that of the control group,the objective remission rate of the study group was 96.08%(49/51),higher than that of the control group(74.51%,38/51),and the difference was statistically significant(P<0.05).After treatment,the values of carcinoembryonic antigen(CEA),cancer antigen 125(CA125)and cytokeratin 19 fragment(CYFRA21-1)in the study group were lower than those in the control group,while the levels of CD_(3)^(+),CD_(4)^(+)and CD_(8)^(+)in the study group were higher than those in the control group,and the level of CD_(8)^(+)was lower than that in the control group with statistical significance(P<0.05).The degree of gastrointestinal tract damage,liver function damage and blood cell toxicity in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The patients diagnosed as obsessive-compulsive disorder were treated with clomipramine and Wendan Decoction(温胆汤)in combination,and the clinical effect was significant,which could effectively improve the clinical symptoms of patients with high safety and clinical application value.

关 键 词：晚期非小细胞肺癌 固本解毒祛瘀法 化疗 免疫功能 

分 类 号：R273.342[医药卫生—中西医结合]