甘草对雷公藤治疗类风湿关节炎减毒增效的研究进展  

Research Progress of Gancao(Glycyrrhizae Radix et Rhizoma)on Attenuating Toxicity and Enhancing Effect of Leigongteng(Tripterygii Radix)in Treatment of Rheumatoid Arthritis

作　　者：林芳芳 刘维[1,2] 卡玉秀 岳青云 陈婌娟 顾庆香 杨晓砚 LIN Fangfang;LIU Wei;KA Yuxiu;YUE Qingyun;CHEN Shujuan;GU Qingxiang;YANG Xiaoyan(First Teaching Hospital to Tianjin University of Traditional Chinese Medicine,Tianjin 30000,China;National Clinical Research Center of Chinese Medicine Acupuncture and Moxibustion,Tianjin 300000,China;Graduate School of Tianjin University of Traditional Chinese Medicine,Tianjin 300000,China)

机构地区：[1]天津中医药大学第一附属医院,天津300000 [2]国家中医针灸临床医学研究中心,天津300000 [3]天津中医药大学研究生院,天津300000

出　　处：《中华中医药学刊》2024年第10期139-143,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药传承与创新“百千万”人才工程(岐黄工程)项目(国中医药人教教育函[2018]12号);刘维岐黄学者工作室建设项目及天津市重点专业项目(20210602-1)。

摘　　要：雷公藤是中医治疗风湿性疾病常用的中草药,对以类风湿关节炎(rheumatoid arthritis,RA)为主的风湿性疾病起到良好的治疗作用,但由于其存在的不良反应使得该药的使用受到限制。甘草是中医传统的解毒药物,以甘草对雷公藤治疗RA为例,通过对近些年的文献进行综述,发现甘草可以通过影响机体的应答以及影响药物在体内的代谢过程对雷公藤治疗RA起到减毒增效的作用。既往尚未有综述对这方面的内容进行讨论,希望通过综述,能为安全使用雷公藤及其相关制剂提供技术参考,为RA的发病机制研究提供理论依据,以及对复方的研究和新药的研发提供思路。Leigongteng(Tripterygii Radix),often used to treat rheumatic diseases,has encouraging results in the treatment of rheumatoid arthritis(RA).However,its use is limited due to its potential toxic side effects.In traditional Chinese medicine,Gancao(Glycyrrhizae Radix et Rhizoma)is often used as an antitoxic drug.This study reviewed recent literature and highlighted the potential of Gancao(Glycyrrhizae Radix et Rhizoma)in alleviating the toxic effects of Leigongteng(Tripterygii Radix)in the treatment of RA and increasing the therapeutic efficacy.By influencing the body's response and drug metabolism,Leigongteng(Tripterygii Radix)plays an important role.It is worth noting that the previous comments did not adequately address this aspect.This study aims to provide valuable insights for the safe utilization of Leigongteng(Tripterygii Radix),provide a theoretical basis for further research on the pathogenesis of RA,and provide new ideas for the development of traditional Chinese medicine compounds and new drugs.

关 键 词：类风湿关节炎 甘草 雷公藤 减毒增效 研究进展 

分 类 号：R282.71[医药卫生—中药学]