补骨脂炮制历史沿革及现代研究进展  

History and Research Progress of Buguzhi(Psoraleae Fructus)Processing

作　　者：王芳 王雯 何晓劲 郑强霞 WANG Fang;WANG Wen;HE Xiaojin;ZHENG Qiangxia(Gansu Medical University,Pingliang 744000,Gansu,China;Traditional Chinese Medicine Hospital in Longde County,Guyuan 756300,Ningxia,China)

机构地区：[1]甘肃医学院,甘肃平凉744000 [2]隆德县中医院,宁夏固原756300

出　　处：《中华中医药学刊》2024年第10期193-199,共7页Chinese Archives of Traditional Chinese Medicine

基　　金：甘肃省高等学校创新基金项目(2022A-184);广西糖尿病系统医学重点实验室开放课题项目(GKLCDSM-20230101-04);甘肃医学院院(系)主任负责制项目(GY-2023FZZ04)。

摘　　要：补骨脂作为一种温肾助阳的优质药物,被广泛应用于中医治疗,它的加工处理方式具有深厚的历史,炮制技术和产品种类颇多,《雷公炮炙论》首次记录了其炮制技术。补骨脂主要化学成分包括黄酮类、香豆素类、单萜酚类、苯并呋喃类和其他类别,具抗癌、抗炎、抗骨质疏松、降血糖等活性,有免疫调节、抑菌和保护心血管等作用。近年来,临床上使用补骨脂及其制剂的患者会出现肝、肾和生殖毒性等不良反应,研究表明,补骨脂苷、补骨脂酚、补骨脂素等是补骨脂毒性的主要物质基础,不同炮制方法会不同程度地改变补骨脂的主要化学成分和不良反应。从补骨脂的炮制历史沿革到现代研究现状进行文献梳理,旨在为补骨脂炮制机理、药效与毒性物质基础以及后续开展研究奠定基础。Buguzhi(Psoraleae Fructus)is a traditional Chinese medicine which can warm kidney and assist Yang.There is a long history of its processing and a variety of processing methods and products.The processing method of Buguzhi(Psoraleae Fructus)was first published in Leigong Paozhi Lun,and the main chemical constituents were flavonoids,coumarins,monoterpene phenols,benzofurans and others,with anti-cancer,anti-inflammatory,anti-osteoporosis and hypoglycemic activities,as well as immune regulation,bacteriostasis and protection of cardiovascular and other effects.In recent years,the clinical use of Buguzhi(Psoraleae Fructus)and its preparations can cause patients with liver,kidney and reproductive toxicity and other side effects.The studies have shown that psoralen glycoside,psoralen phenol,psoralen and so on are the main material basis of Buguzhi(Psoraleae Fructus)toxicity.Different processing methods can change the main chemical components and toxic and side effects of Buguzhi(Psoraleae Fructus).In this paper,the history of Buguzhi(Psoraleae Fructus)processing and the present research situation were reviewed,in order to lay a foundation for the processing mechanism,pharmacodynamics and toxicity of Buguzhi(Psoraleae Fructus)as well as the follow-up research.

关 键 词：补骨脂 历史沿革 化学成分 药理作用 炮制 

分 类 号：R283[医药卫生—中药学] R282.7[医药卫生—中医学]