基于T1WI一阶组学特征在钆对比剂脑内沉积评估中的价值探讨  

Evaluation of Gadolinium Contrast Agent Deposition in Brain Based on T1WI Firstorder Omics Features

作　　者：何敏丽 肖运平[3] 苏寿红[2] HE Min-li;Xiao Yun-ping;Su Shou-hong(Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011,Guangxi Zhuang Autonomous Region,China;Department of Radiology,the Affiliated Hospital of Guilin Medical University,Guilin 541001,Guangxi Zhuang Autonomous Region,China;Liuzhou People's Hospital,Liuzhou 545026,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西中医药大学附属瑞康医院,广西南宁530011 [2]桂林医学院附属医院放射科,广西桂林541001 [3]柳州市人民医院,广西柳州545026

出　　处：《中国CT和MRI杂志》2024年第9期8-10,共3页Chinese Journal of CT and MRI

基　　金：钆对比剂在脑内齿状核、苍白球沉积与T1WI和T2WI信号强度变化的相关性研究(Z20190732)。

摘　　要：目的探讨一阶组学特征分析在钆对比剂脑内沉积评估中的价值及最佳量化参数。方法回顾性分析2010年1月至2021年12月收集的114例至少行4次线性钆对比剂MR增强检查的患者影像,测量患者每次检查平扫T1WI图像齿状核/脑桥信号强度比值,使用Spearman秩相关性分析评估信号强度比值和增强次数之间的关系;绘制首次和末次MRI平扫T1WI的齿状核/脑桥信号强度比值ROC曲线,并计算其曲线下面积AUC值,评估其诊断效能。采用ITKSNAP软件,分别在首次及末次平扫T1WI图像上勾画双侧齿状核的ROI,提取一阶组学特征,绘制首次和末次检查有统计学差异特征的ROC曲线,计算其AUC值,评估筛选后的一阶组学特征的诊断效能。并利用Delong方法比较筛选后的一阶组学特征与信号强度比值的诊断效能。结果多次行线性钆对比剂检查增强次数与平扫T1WI图像齿状核/脑桥信号强度比值之间存在正相关关系(r=0.570)。齿状核/脑桥信号强度比值AUC为0.839。一阶组学特征中能量的AUC值(0.992)最高并高于信号强度比值(Z=5.6091,P<0.001)。结论一阶组学特征中的能量、总能量在钆对比剂脑内沉积评估中的诊断效能优于齿状核/脑桥信号强度比值,其中能量具有最高的诊断效能。Objective To investigate the value and optimal quantitative parameters of first-order omics feature analysis in the evaluation of gadolinium contrast agent deposition in the brain.Methods The images of 114 patients who underwent at least four linear gadolinium contrast agent MR enhancement examinations were retrospectively analyzed.The ratio of dentate nucleus/pons signal intensity in T1WI images of each examination was measured.Spearman rank correlation analysis was used to evaluate the relationship between signal intensity ratio and enhancement times.The receiver operating characteristic(ROC)curves of the dentate nucleus/pons signal intensity ratio of the first and last MRI unscanned T1WI were drawn,and the area under thecurve(AUC)was calculated to evaluate its diagnostic efficacy.Using ITK-SNAP software,the ROIs of bilateral dentate nucleus were delineated on the first and last unscanned T1WI images,and the first-order omics features were extracted.The ROC curves with statistically significant differences between the first and last examination were drawn,and the AUC values were calculated to evaluate the diagnostic efficacy of the screened first-order omics features.Delong method was used to compare the diagnostic efficacy of the screened first-order omics features with the ratio of signal intensity.Results There was a positive correlation between the intensity ratio of dentate nucleus/pons on plain T1WI images(r=0.570).The signal intensity ratio of dentate nucleus to pons(AUC)was 0.839.The AUC value of energy(0.992)was the highest among the first-order omics features and higher than the signal intensity ratio(P<0.001).Conclusion The diagnostic efficacy of first-order omics features of energy and total energy in the evaluation of gadolinium contrast agent intracerebral deposition is better than that of dentate nucleus/pons signal intensity ratio,and energy has the highest diagnostic efficacy.

关 键 词：钆 齿状核 磁共振成像 一阶组学特征 

分 类 号：R445.2[医药卫生—影像医学与核医学]