DCE-MRI定量参数联合血清CEA、Cyfra21-1诊断非小细胞肺癌纵隔淋巴结转移的回顾性研究  

Retrospective Study of DCE-MRI Quantitative Parameters Combine with Serum CEA and Cyfra21-1 in the Diagnosis of Mediastinal Lymph Node Metastasis in Non-small Cell Lung Cancer

作　　者：吴俊宏 李雪萍[1] 孔少龙 杨健[1] Wu Jun-hong;LI Xue-ping;KONG Shao-long;YANG Jian(Department of Imaging,Guigang City People's Hospital,Guigang 537119,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]贵港市人民医院影像科,广西贵港537119

出　　处：《中国CT和MRI杂志》2024年第9期50-52,共3页Chinese Journal of CT and MRI

基　　金：2020年度广西医药卫生自筹经费科研课题(20200811)。

摘　　要：目的探讨动态对比增强磁共振成像(DCEMRI)定量参数联合血清癌胚抗原(CEA)、细胞白蛋白19片段(Cyfra21-1)诊断非小细胞肺癌纵隔淋巴结转移(MLNM)的价值。方法回顾性分析2020年5月至2022年12月贵港市人民医院收治的147例非小细胞肺癌患者的临床资料,根据术后病理诊断结果分为MLNM组(44例)和非MLNM组(103例)。检测非小细胞肺癌患者术前DCE-MRI定量参数和血清CEA、Cyfra21-1水平。采用受试者工作特征(ROC)曲线分析DCE-MRI定量参数联合血清CEA、Cyfra21-1诊断非小细胞肺癌患者发生MLNM的价值。结果MLNM组Ktrans、Kep、Ve,血清CEA、Cyfra21-1水平高于非MLNM组(P<0.05)。Ktrans、Kep、Ve、CEA、Cyfra21-1诊断非小细胞肺癌发生MLNM的曲线下面积分别为0.758、0.618、0.609、0.643、0.730,联合Ktrans、Kep、Ve、CEA、Cyfra21-1诊断非小细胞肺癌发生MLNM的曲线下面积为0.872,高于单独诊断。结论非小细胞肺癌MLNM患者的DCE-MRI参数Ktrans、Kep、Ve增加,血清CEA、Cyfra21-1水平升高,联合DCE-MRI参数和血清CEA、Cyfra21-1检测可提高对MLNM的诊断效能。Objective To investigate the value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)quantitative parameters combine with serum carcinoembryonic antigen(CEA)and cell albumin 19 fragment(Cyfra21-1)in the diagnosis of mediastinal lymph node metastasis(MLNM)in non-small cell lung cancer.Methods The clinical data of 147 non-small cell lung cancer patients who were admitted to Guigang People's Hospital from May 2020 to December 2022 were retrospectively analyzed,patients were divided into MLNM group(44 cases)and non-MLNM group(103 cases)according to the results of postoperative pathological diagnosis.Preoperative DCE-MRI quantitative parameters and serum CEA and Cyfra21-1 levels were detected in non-small cell lung cancer patients.The value of DCE-MRI quantitative parameters combined with serum CEA and Cyfra21-1 in the diagnosis of MLNM in nonsmall cell lung cancer patients were analyzed by receiver operating characteristic(ROC)curve.Results The levels of Ktrans,Kep,Ve,serum CEA and Cyfra21-1 in MLNM group were higher than those in nonMLNM group(P<0.05).The area under the curve of Ktrans,Kep,Ve,CEA and Cyfra21-1 in the diagnosis of MLNM in non-small cell lung cancer was 0.758,0.618,0.609,0.643 and 0.730 respectively,the area under the curve of combined Ktrans,Kep,Ve,CEA and Cyfra21-1 in the diagnosis of MLNM in non-small cell lung cancer was 0.872,which was higher than that of single diagnosis.Conclusion The DCE-MRI parameters Ktrans,Kep and Ve of non-small cell lung cancer MLNM patients increased,and the levels of serum CEA and Cyfra21-1 increased,the combination of DCE-MRI parameters and serum CEA and Cyfra21-1 detection can improve the diagnostic efficacy of MLNM.

关 键 词：非小细胞肺癌 纵隔淋巴结转移 动态对比增强磁共振成像 癌胚抗原 细胞白蛋白19片段 

分 类 号：R445.2[医药卫生—影像医学与核医学]