基于定量CT对中老年人群体脂肪分布与外周血炎症细胞标志物的相关性分析  

Correlation Analysis of Fat Distribution and Peripheral Blood Inflammatory Cell Markers in Middle-Aged and Elderly Populations Based on Quantitative CT

作　　者：刘澳 周菁 孙永兵 戚昕 杜亚玮 周阳 李中林[5] 武肖玲 邹智 吕雪[7] 李昊 李永丽[2] LIU Ao;ZHOU Jing;SUN Yongbing(Department of Medical Imaging,Zhengzhou University People's Hospital,Zhengzhou,Henan Province 450003,P.R.China)

机构地区：[1]郑州大学人民医院医学影像科,郑州450003 [2]河南省人民医院健康管理学科河南省慢病健康管理重点实验室 [3]新乡医学院 [4]河南大学人民医院医学影像科 [5]河南省人民医院医学影像科 [6]河南省人民医院核医学科 [7]河南省人民医院 [8]阜外华中心血管病医院

出　　处：《临床放射学杂志》2024年第10期1794-1799,共6页Journal of Clinical Radiology

基　　金：国家自然科学基金项目资助项目(编号:82071884);国家重点研发计划资助项目(编号:2022YFC2010000、2022YFC2010001);中原科技创新领军人才计划资助(244200510016);河南省医学科技攻关计划项目资助项目(编号:SBGJ202302011)。

摘　　要：目的探讨中老年人群体脂肪分布与外周血炎症细胞标志物的相关性。方法回顾性选取2021年1月至2022年1月在河南省人民医院健康管理学科行胸部CT联合定量CT(QCT)检查的2141名中老年体检者为研究对象,搜集其年龄、身体质量指数(BMI)、全血细胞计数和血脂指标,同时使用QCT测量受试者的体脂肪分布情况。以60岁为界限将男性和女性各分为<60岁组和≥60岁组,采用独立样本t检验,Pearson相关性分析、偏相关分析体脂肪分布和中性粒细胞计数与高密度脂蛋白胆固醇比值(NHR)、单核细胞计数与高密度脂蛋白胆固醇比值(MHR)、淋巴细胞计数与高密度脂蛋白胆固醇比值(LHR)的相关性。结果在<60岁组与≥60岁组两组中,男性BMI、NHR、MHR、LHR、内脏脂肪面积、肝脏脂肪面积和肌肉脂肪含量均高于女性,但皮下脂肪面积均低于女性(均P<0.05)。Pearson相关性分析结果显示在年龄<60岁男性组中,皮下脂肪面积与NHR、MHR、LHR呈正相关(r=0.180,0.245,0.246)(均P<0.05),内脏脂肪面积与NHR、MHR、LHR呈正相关(r=0.266,0.297,0.232)(均P<0.05),肝脏脂肪含量与NHR、MHR、LHR呈正相关(r=0.165,0.196,0.169)(均P<0.05);在年龄≥60岁男性组,皮下脂肪面积与NHR、MHR、LHR呈正相关(r=0.152,0.158,0.155)(均P<0.05),内脏脂肪面积与NHR、MHR、LHR呈正相关(r=0.325,0.312,0.244)(均P<0.05),肝脏脂肪含量与NHR、MHR、LHR呈正相关(r=0.176,0.204,0.151)(均P<0.05);在年龄<60岁女性组,皮下脂肪面积与NHR、MHR、LHR呈正相关(r=0.225,0.196,0.243)(均P<0.05),内脏脂肪面积与NHR、MHR、LHR呈正相关(r=0.371,0.302,0.347)(均P<0.05),肝脏脂肪含量与NHR、MHR、LHR呈正相关(r=0.331,0.250,0.237)(均P<0.05);在年龄≥60岁女性组,内脏脂肪面积与NHR、MHR、LHR呈正相关(r=0.322,0.294,0.208)(均P<0.05),肝脏脂肪含量与NHR、MHR、LHR呈正相关(r=0.180,0.241,0.146)(均P<0.05),而皮下脂肪面积与NHR、MHR、LHR无相关性(均P>0.05);在不同Objective To investigate the correlation between fat distribution and peripheral blood inflammatory cell markers in middle-aged and elderly population.Methods A total of 2141 middle-aged and elderly physical examiners who underwent chest CT combined with quantitative computed tomography(QCT)at the Department of Health Management of Henan Provincial People's Hospital from January 2021 to January 2022 were retrospectively selected as the study subjects,and their age,body mass index(BMI)and blood lipid index were measured using QCT at the same time.Body mass index(BMI),complete blood count,and lipid profile were collected,and the body fat distribution of the subjects was measured using QCT.Men and women were divided into<60 years old and≥60 years old groups with 60 years old as the cut-off age,and the correlation between body fat distribution and neutrophil-to-high-density lipoprotein ratio(NHR),monocyte-to-high-density lipoprotein ratio(MHR),and lymphocyte-to-high-density lipoprotein ratio(LHR)was analyzed by independent samples t-test,Pearson correlation analysis and partial correlation.Results In both groups,<60 years old and≥60 years old,men had higher BMI,NHR,MHR,LHR,visceral fat area,liver fat area,and muscle fat content than women,but subcutaneous fat area was lower than that of women(all P<0.05).The results of the Pearson's correlation analysis showed that in the group of men aged<60 years old,the subcutaneous fat area was positively correlated with NHR,MHR,and LHR(r=0.180,r=0.245,and r=0.246)(all P<0.05),and the visceral fat area was positively correlated with NHR,MHR,and LHR(r=0.266,r=0.297,r=0.232)(all P<0.05),and liver fat content was positively correlated with NHR,MHR,and LHR(r=0.165,r=0.196,r=0.169)(all P<0.05);in the group of men aged≥60 years,the area of subcutaneous fat was positively correlated with NHR,MHR,and LHR(r=0.152,r=0.158,r=0.155)(all P<0.05),and the area of visceral fat was positively correlated with NHR,MHR,and LHR(r=0.325,r=0.312,r=0.244)(all P<0.05),and liver fat content was posi

关 键 词：定量CT 体脂肪分布 NHR MHR LHR 相关性分析 

分 类 号：R816[医药卫生—放射医学]