siRNA纳米递送系统在类风湿性关节炎治疗中的研究进展  

Research progress of siRNA nanodelivery systems in the treatment of rheumatoid arthritis

作　　者：孙鑫 梁霄 文武龙 张炜烨 杨婧[2] 王锐[1] SUN Xin;LIANG Xiao;WEN Wu-long;ZHANG Wei-ye;YANG Jing;WANG Rui

机构地区：[1]黑龙江中医药大学药学院,哈尔滨150040 [2]黑龙江中医药大学基础医学院,哈尔滨150040

出　　处：《中国医药生物技术》2024年第5期392-396,419,共6页Chinese Medicinal Biotechnology

基　　金：国家自然科学基金(82074271)。

摘　　要：类风湿性关节炎是一种自身免疫性疾病,其病因复杂,目前尚未有很好的治疗方法,长期服用抗风湿药物也带来诸多副作用。RNA干扰技术是指通过外源性或内源性的双链RNA在体内诱导靶基因m RNA产生特异性降解,进而引起不同水平的基因沉默,具有高效、高特异性、低毒等优点,在生物医药领域有着巨大潜力。小干扰RNA(si RNA)作为RNA干扰技术的重要效应分子,在治疗类风湿关节炎方面具有巨大潜力。本文综述了siRNA递送系统用于治疗类风湿关节炎的最新研究进展,阐明了基于siRNA纳米给药系统治疗类风湿关节炎的优势,并展望了未来siRNA递送的发展方向。Rheumatoid arthritis is a complex autoimmune disease with no definitive treatment currently available.Long-term use of antirheumatic drugs can lead to numerous side effects.RNA interference technology involves the targeted degradation of specific gene mRNA using exogenous or endogenous double-stranded RNA,resulting in gene silencing.This technology offers high efficiency,specificity and low toxicity,making it highly promising in biomedicine.Small interfering RNAs(siRNAs),crucial effectors of RNA interference,show significant potential in the treatment of rheumatoid arthritis.This article provides an overview of the recent advancements in siRNA delivery system for the treatment of rheumatoid arthritis,highlighting the advantages of siRNA nanodelivery systems in this context and discussing potential future directions in siRNA delivery research.

关 键 词：类风湿性关节炎 RNA干扰技术 小干扰RNA 纳米递送 

分 类 号：R943[医药卫生—药剂学]